This grant opportunity, offered by the National Institutes of Health (NIH), seeks proposals to investigate the complex neuroimmune and neuronal-glial mechanisms underlying HIV-associated neurological disorders (HAND). Utilizing advanced ex vivo culturing platforms, researchers will employ human induced pluripotent stem cells (hiPSC) to model the effects of addictive substances on brain function. The focus is on rigorously analyzing genetic, epigenetic, and cellular interactions within neuroimmune and neuroglial systems. Studies should span from single-cell analyses to neural circuit levels, providing unbiased and reproducible insights into how HIV and substance use contribute to neurological pathology. This funding supports foundational research to advance our understanding of HAND pathogenesis.
Opportunity ID: 357939
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DA-25-074 |
| Funding Opportunity Title: | Ex Vivo Models for Studies at the Intersection of HIV and Addictive Substance Use (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Use and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 30, 2024 |
| Last Updated Date: | Dec 30, 2024 |
| Original Closing Date for Applications: | Aug 13, 2025 |
| Current Closing Date for Applications: | Aug 13, 2025 |
| Archive Date: | Sep 18, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Special district governments Private institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Notice of Funding Opportunity (NOFO) invites grant applications aimed at elucidating neuroimmune and neuronal-glial pathophysiological mechanisms of HIV-associated neurological disorders (HAND) using ex vivo culturing platforms derived from human induced pluripotent stem cells (hiPSC) in the presence of addictive substances. Specific emphasis is on unbiased, reproducible analysis of genetics and epigenetics, neuroglial interactions, and neuroimmune cell activities from the single cell to neural circuit levels. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-074.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357939 Full Announcement-RFA-DA-25-074 -> RFA-DA-25-074-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289835 | Jul 13, 2025 | Aug 13, 2025 | View |
Package 1
Mandatory forms
357939 RR_SF424_5_0-5.0.pdf
357939 PHS398_CoverPageSupplement_5_0-5.0.pdf
357939 RR_OtherProjectInfo_1_4-1.4.pdf
357939 PerformanceSite_4_0-4.0.pdf
357939 RR_KeyPersonExpanded_4_0-4.0.pdf
357939 PHS398_ResearchPlan_5_0-5.0.pdf
357939 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357939 RR_Budget_3_0-3.0.pdf
357939 RR_SubawardBudget30_3_0-3.0.pdf
357939 PHS398_ModularBudget_1_2-1.2.pdf
357939 PHS_AssignmentRequestForm_4_0-4.0.pdf
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