The National Institutes of Health (NIH) is offering this R01 grant to support studies identifying genetic variants contributing to drug abuse and addiction. This grant is for discovering structural and SNP variants, particularly rare to moderate frequency ones, affecting addiction risk. Leveraging genome-wide association studies (GWAS) insights, proposals should utilize next-generation sequencing on well-characterized samples with drug abuse phenotypes. Eligible approaches include family-based designs, deep sequencing of GWAS-identified regions, or targeting candidate genes in extreme phenotypes. Applicants must use existing DNA samples with broad data sharing consents.
Opportunity ID: 51345
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DA-10-019 |
| Funding Opportunity Title: | Deep Sequencing and Analysis of Pharmacogenomic Regions: Discovery and Analysis of Genetic Variants Contributing to Drug Abuse and Addiction (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Abuse and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 26, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Apr 29, 2010 |
| Current Closing Date for Applications: | Apr 29, 2010 |
| Archive Date: | May 30, 2010 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $250,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Private institutions of higher education State governments City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. Genome-wide association studies (GWAS) have been critical for identifying genomic regions associated with addiction phenotypes, and have highlighted several areas that require further refinement using deep sequencing approaches. The goal of this FOA is to support studies proposing to use next-generation sequencing technologies to identify the structural variants and SNP variants with rare to moderate frequencies that affect addiction risk in well-characterized samples with drug abuse phenotypes. Applications may propose strategies for deep sequencing based on family based designs; deep sequencing of regions identified by GWAS to be associated with addiction risk; sequencing candidate genes in individuals with extreme phenotypes; or other analytic approaches that capitalize on the genetic architecture. Applicants must use existing DNA samples with appropriately obtained consents for broad data sharing. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-10-019.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.279 | ADOBE-FORMS-B | Use for submissions intended for due dates of January 25, 2010 and beyond | PKG00016055 | Mar 29, 2010 | Apr 29, 2010 | View |
Package 1
Mandatory forms
51345 RR_SF424_1_2-1.2.pdf
51345 PerformanceSite_1_3-1.3.pdf
51345 RR_OtherProjectInfo_1_2-1.2.pdf
51345 RR_KeyPersonExpanded_1_2-1.2.pdf
51345 PHS398_CoverPageSupplement_1_4-1.4.pdf
51345 PHS398_ResearchPlan_1_3-1.3.pdf
51345 PHS398_Checklist_1_3-1.3.pdf
Optional forms
51345 PHS_CoverLetter_1_2-1.2.pdf
51345 PHS398_ModularBudget-1.1.pdf
51345 RR_Budget-1.1.pdf
51345 RR_SubawardBudget-1.2.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
