The National Institutes of Health (NIH) is offering this grant to establish a Coordinating Center (CC) for Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry. This center will provide centralized support, infrastructure, and data analysis, with the primary goal of collaboratively generating and refining PRS specifically for diverse populations. It will integrate existing genomic and phenotype datasets covering various complex diseases and traits. Grantees will form a Consortium with other PRS Centers. The Consortium’s key objectives are to leverage genetic diversity for developing advanced PRS methods, improving their applicability for predicting health and disease risk across diverse groups, and optimizing the integration of large-scale, harmonized data to facilitate collaborative analysis, data dissemination, and resource development.
Opportunity ID: 325700
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HG-20-002 |
| Funding Opportunity Title: | Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry Coordinating Center (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Mar 23, 2020 |
| Last Updated Date: | May 26, 2020 |
| Original Closing Date for Applications: | Jun 23, 2020 |
| Current Closing Date for Applications: | Jul 07, 2020 |
| Archive Date: | Aug 06, 2020 |
| Estimated Total Program Funding: | $2,375,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) City or township governments Special district governments Independent school districts Small businesses Public housing authorities/Indian housing authorities State governments Public and State controlled institutions of higher education For profit organizations other than small businesses County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
The goal of the intended FOA is to establish a Coordinating Center (CC) for PRS Methods and Analysis for Populations of Diverse Ancestry to provide centralized support, infrastructure, coordination, and data analysis for the program collaboratively generate and refine PRS for populations of diverse ancestry by integrating existing datasets with genomic and phenotype data for a range of complex diseases and traits. Together with PRS Centers (described in a separate FOA), grantees funded under the intended FOA will form a Consortium with the primary objectives of: 1) leveraging genetic diversity to develop methods and improve the applicability of PRS to predict health and disease risk across diverse populations, and for a broad range of health and disease measures; and 2) optimizing the integration of large-scale, harmonized genomic and phenotype data to facilitate collaborative analysis, dissemination of PRS-related data, and development of related methods and resources. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-20-002.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| updated close date | May 26, 2020 | |
| Mar 23, 2020 | ||
| Apr 06, 2020 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HG-20-002 |
| Funding Opportunity Title: | Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry Coordinating Center (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Mar 23, 2020 |
| Last Updated Date: | May 26, 2020 |
| Original Closing Date for Applications: | Jun 23, 2020 |
| Current Closing Date for Applications: | Jul 07, 2020 |
| Archive Date: | Aug 06, 2020 |
| Estimated Total Program Funding: | $2,375,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) City or township governments Special district governments Independent school districts Small businesses Public housing authorities/Indian housing authorities State governments Public and State controlled institutions of higher education For profit organizations other than small businesses County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
The goal of the intended FOA is to establish a Coordinating Center (CC) for PRS Methods and Analysis for Populations of Diverse Ancestry to provide centralized support, infrastructure, coordination, and data analysis for the program collaboratively generate and refine PRS for populations of diverse ancestry by integrating existing datasets with genomic and phenotype data for a range of complex diseases and traits. Together with PRS Centers (described in a separate FOA), grantees funded under the intended FOA will form a Consortium with the primary objectives of: 1) leveraging genetic diversity to develop methods and improve the applicability of PRS to predict health and disease risk across diverse populations, and for a broad range of health and disease measures; and 2) optimizing the integration of large-scale, harmonized genomic and phenotype data to facilitate collaborative analysis, dissemination of PRS-related data, and development of related methods and resources. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-20-002.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HG-20-002 |
| Funding Opportunity Title: | Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry Coordinating Center (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 23, 2020 |
| Last Updated Date: | Mar 23, 2020 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Jun 23, 2020 |
| Archive Date: | Jul 29, 2020 |
| Estimated Total Program Funding: | $2,375,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) County governments State governments City or township governments Private institutions of higher education Small businesses Special district governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of the intended FOA is to establish a Coordinating Center (CC) for PRS Methods and Analysis for Populations of Diverse Ancestry to provide centralized support, infrastructure, coordination, and data analysis for the program collaboratively generate and refine PRS for populations of diverse ancestry by integrating existing datasets with genomic and phenotype data for a range of complex diseases and traits. Together with PRS Centers (described in a separate FOA), grantees funded under the intended FOA will form a Consortium with the primary objectives of: 1) leveraging genetic diversity to develop methods and improve the applicability of PRS to predict health and disease risk across diverse populations, and for a broad range of health and disease measures; and 2) optimizing the integration of large-scale, harmonized genomic and phenotype data to facilitate collaborative analysis, dissemination of PRS-related data, and development of related methods and resources. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-20-002.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
DISPLAYING: Forecast 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | NOT-HG-20-006 |
| Funding Opportunity Title: | Notice of Intent to Publish a Funding Opportunity Announcement for a Coordinating Center for Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Forecast 1 |
| Posted Date: | Apr 06, 2020 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | – |
| Archive Date: | Mar 22, 2020 |
| Estimated Total Program Funding: | $88,000,000 |
| Award Ceiling: | $1,600,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments County governments Private institutions of higher education Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) For profit organizations other than small businesses |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | – |
| Description: | The National Human Genome Research Institute intends to issue a Funding Opportunity Announcement (FOA) to solicit applications to support a Coordinating Center for Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry. The intended FOA will be based on a concept recently approved by the National Advisory Council on Human Genome Research and accompanying discussion (https://www.genome.gov/sites/default/files/media/files/2019-09/Sept2019_Council_Hindorff_PolygenicRiskScore_RFA_Concept.pdf and https://www.youtube.com/watch?v=x0-hw7DoOQU). This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The FOA is expected to be published in January, 2020 with an expected application due date in Summer, 2020. This FOA will utilize the U01 activity code. Details of the planned FOA are provided below. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
–
Email:hindorffl@mail.nih.gov |
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00260449 | May 23, 2020 | Jul 07, 2020 | View |
Package 1
Mandatory forms
325700 RR_SF424_2_0-2.0.pdf
325700 PHS398_CoverPageSupplement_5_0-5.0.pdf
325700 RR_OtherProjectInfo_1_4-1.4.pdf
325700 PerformanceSite_2_0-2.0.pdf
325700 RR_KeyPersonExpanded_2_0-2.0.pdf
325700 PHS398_ResearchPlan_4_0-4.0.pdf
325700 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
325700 RR_Budget_1_4-1.4.pdf
325700 RR_SubawardBudget30_1_4-1.4.pdf
325700 PHS398_ModularBudget_1_2-1.2.pdf
325700 PHS_AssignmentRequestForm_3_0-3.0.pdf
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