The National Institutes of Health (NIH) is offering this Exploratory/Developmental (R21) grant to institutions and organizations. This grant is for the purpose of developing new small molecule probes to investigate biological function within the nervous system. Eligible investigators should have pre-identified probe candidates from small molecule screenings, demonstrating a clear relationship between structural features and biological activity. Proposals are expected to focus on iterative design and testing of analogues from distinct structural series through structure-activity relationship studies using in vitro assays. The ultimate goal is to develop small molecule probes with optimal attributes—such as affinity, selectivity, and activity—suitable for future pharmacological research. The NIH encourages utilizing publicly available cheminformatic capabilities.
Opportunity ID: 49065
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-09-251 |
| Funding Opportunity Title: | Optimization of Small Molecule Probes for the Nervous System (R21) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 13, 2009 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Sep 07, 2012 |
| Current Closing Date for Applications: | Sep 07, 2012 |
| Archive Date: | Oct 08, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $150,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Special district governments Independent school districts State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Small businesses City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This FOA issued by participating institutes of the National Institutes of Health, encourages research grant applications from institutions/ organizations that propose to develop new small molecule probes for investigating biological function in the nervous system via the application of advanced medicinal chemistry and the biological testing of compounds. Eligible investigators will have identified probe candidates via screening of small molecule collections, using in vitro assays of biological activity developed to interrogate these collections, and be able to show that the structural features of these small molecules are related to their biological activity. Proposals should nominate small molecule probe candidates from distinct structural series for the further, iterative design and testing of analogues in structure-activity relationship studies, using in vitro assays of biological function adapted to the medium throughput screening requirements of this work. These studies should have the goal of developing a small molecule probe possessing the attributes (eg: affinity, selectivity, activity) required for its use in future pharmacological studies proposed by the investigator. Applicants are strongly encouraged to utilize publicly available cheminformatic capabilities for the acquisition of compounds, and semi-custom synthesis of analogues. Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism. In the near future, NINDS expects to publish two additional FOAs of identical scientific scope that encourage applications under the Small Business Innovation Research (SBIR) (R43) grant mechanism and Small Business Technology Transfer (STTR) (R41) grant mechanism. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism, numbers, quality, duration, and costs of the applications received. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-09-251.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-A | Adobe-Forms-A | PKG00013575 | Sep 16, 2009 | Feb 20, 2010 | View | |
| ADOBE-FORMS-B | Use for submissions intended for due dates of January 25, 2010 and beyond | PKG00015308 | Dec 21, 2009 | Nov 03, 2010 | View | |
| ADOBE-FORMS-B1 | Supersedes ADOBE-FORMS-B | PKG00022343 | Nov 03, 2010 | Sep 07, 2012 | View |
Package 1
Mandatory forms
49065 RR_SF424-1.1.pdf
49065 RR_KeyPersonExpanded-1.1.pdf
49065 RR_OtherProjectInfo-1.1.pdf
49065 RR_PerformanceSite-1.1.pdf
49065 PHS398_CoverPageSupplement-1.1.pdf
49065 PHS398_ResearchPlan-1.1.pdf
49065 PHS398_Checklist-1.1.pdf
Optional forms
49065 PHS398_CoverLetter-1.1.pdf
49065 PHS398_ModularBudget-1.1.pdf
49065 RR_Budget-1.1.pdf
49065 RR_SubawardBudget-1.2.pdf
Package 2
Mandatory forms
49065 RR_SF424_1_2-1.2.pdf
49065 PerformanceSite_1_3-1.3.pdf
49065 RR_OtherProjectInfo_1_2-1.2.pdf
49065 RR_KeyPersonExpanded_1_2-1.2.pdf
49065 PHS398_CoverPageSupplement_1_4-1.4.pdf
49065 PHS398_ResearchPlan_1_3-1.3.pdf
49065 PHS398_Checklist_1_3-1.3.pdf
Optional forms
49065 PHS_CoverLetter_1_2-1.2.pdf
49065 PHS398_ModularBudget-1.1.pdf
49065 RR_Budget-1.1.pdf
49065 RR_SubawardBudget-1.2.pdf
Package 3
Mandatory forms
49065 RR_SF424_1_2-1.2.pdf
49065 RR_OtherProjectInfo_1_3-1.3.pdf
49065 RR_KeyPersonExpanded_1_2-1.2.pdf
49065 PerformanceSite_1_4-1.4.pdf
49065 PHS398_ResearchPlan_1_3-1.3.pdf
49065 PHS398_CoverPageSupplement_1_4-1.4.pdf
49065 PHS398_Checklist_1_3-1.3.pdf
Optional forms
49065 RR_Budget-1.1.pdf
49065 RR_SubawardBudget-1.2.pdf
49065 PHS_CoverLetter_1_2-1.2.pdf
49065 PHS398_ModularBudget-1.1.pdf
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