The NCCIH is offering this grant to establish Clinical Coordinating Centers (CCC) for investigator-initiated, multi-site clinical trials of complementary and integrative health approaches. This funding supports research on mind and body or multi-component interventions in NCCIH priority areas. CCCs must develop and implement fully powered multi-site clinical trials (Phase III+), outlining scientific rationale, comprehensive operational plans, project management, participant recruitment, and result dissemination. This two-phase, milestone-driven cooperative agreement (UG3/UH3) mandates a simultaneous, separate Data Coordinating Center (DCC) application for data management and analysis.
Opportunity ID: 356395
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-24-275 |
| Funding Opportunity Title: | Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative UG3/UH3 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.213 — Research and Training in Complementary and Integrative Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 11, 2024 |
| Last Updated Date: | Sep 11, 2024 |
| Original Closing Date for Applications: | Jul 14, 2026 |
| Current Closing Date for Applications: | Jul 14, 2026 |
| Archive Date: | Aug 19, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities State governments Native American tribal governments (Federally recognized) City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education County governments Public and State controlled institutions of higher education Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This notice of funding opportunity (NOFO) encourages applications for investigator-initiated multi site clinical trials (e.g., efficacy, effectiveness, or pragmatic trials) to study the effects of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions), and/or multicomponent interventions that include physical, psychological, and/or nutritional approaches in NCCIH- designated areas of high research priority. Clinical Coordinating Centers (CCC) should develop and implement the proposed fully powered multi-site clinical trial (Phase III and beyond). The objective of a CCC application is to present the scientific rationale and a comprehensive scientific and operational plan for the clinical trial. CCC applications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. CCC applications submitted under this NOFO will utilize a two-phase, milestone-driven cooperative agreement (UG3/UH3) funding mechanism. In addition, an accompanying Data Coordinating Center (DCC) application (U24), submitted under PAR-24-087 proposing a data analysis and data management plan for the clinical project is required. Both a CCC application and a corresponding DCC application need to be submitted simultaneously for consideration by NCCIH. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website: (https://nccih.nih.gov/about/plans). Applicants are encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-24-275.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356395 Full Announcement-PAR-24-275 -> PAR-24-275-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288415 | Jan 20, 2025 | Jul 14, 2026 | View |
Package 1
Mandatory forms
356395 RR_SF424_5_0-5.0.pdf
356395 PHS398_CoverPageSupplement_5_0-5.0.pdf
356395 RR_OtherProjectInfo_1_4-1.4.pdf
356395 PerformanceSite_4_0-4.0.pdf
356395 RR_KeyPersonExpanded_4_0-4.0.pdf
356395 RR_Budget10_3_0-3.0.pdf
356395 PHS398_ResearchPlan_5_0-5.0.pdf
356395 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356395 RR_SubawardBudget10_30_3_0-3.0.pdf
356395 PHS_AssignmentRequestForm_4_0-4.0.pdf
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