The National Center for Complementary and Integrative Health (NCCIH) is offering a Phased Innovation Award for the pilot testing of natural products in high priority research topics. This grant aims to provide support for initial phase testing of natural products to determine their biological signature or mechanism of action. The funding will cover up to two years for bioavailability and pharmacokinetic testing (R21 phase) and up to 3 years for further clinical studies (R33 phase). The goal is to accelerate the translation of basic science findings into clinical pilot testing, informing decisions on continued research and development of natural products.
Opportunity ID: 273330
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AT-16-001 |
| Funding Opportunity Title: | Phased Innovation Award for Exploratory Clinical Trials of Natural Products in NCCIH High Priority Research Topics (R21/R33) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.213 — Research and Training in Complementary and Alternative Medicine |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Feb 06, 2015 |
| Last Updated Date: | Feb 09, 2015 |
| Original Closing Date for Applications: | Jun 22, 2015 |
| Current Closing Date for Applications: | Aug 04, 2015 |
| Archive Date: | Sep 04, 2015 |
| Estimated Total Program Funding: | $1,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments Independent school districts Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this funding opportunity is to support pilot testing of natural products (i.e., botanicals, dietary supplements, and probiotics), which have sufficient early-stage data to justify further clinical testing of the product. Under this FOA, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product. The data collected should be used to fill gaps in scientific knowledge and provide the information necessary to develop a competitive full-scale clinical trial.Support will be provided for up to two years (R21 phase) for milestone-driven bioavailability and pharmacokinetic testing and assessment of the natural products biological signature or mechanism of action. Based on the results of the R21 phase, this may be followed by support of up to 3 years (R33 phase) of support for further clinical studies of the natural product. This FOA is not appropriate for support of randomized clinical trials to test or determine efficacy. Ultimately, this R21/R33 funding mechanism is intended to speed the translation of emerging basic science findings about natural products into clinical pilot testing to determine whether continued clinical research is warranted. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AT-16-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Close date was corrected. | Feb 09, 2015 | |
| Feb 09, 2015 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AT-16-001 |
| Funding Opportunity Title: | Phased Innovation Award for Exploratory Clinical Trials of Natural Products in NCCIH High Priority Research Topics (R21/R33) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.213 — Research and Training in Complementary and Alternative Medicine |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Feb 06, 2015 |
| Last Updated Date: | Feb 09, 2015 |
| Original Closing Date for Applications: | Jun 22, 2015 |
| Current Closing Date for Applications: | Aug 04, 2015 |
| Archive Date: | Sep 04, 2015 |
| Estimated Total Program Funding: | $1,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments Independent school districts Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this funding opportunity is to support pilot testing of natural products (i.e., botanicals, dietary supplements, and probiotics), which have sufficient early-stage data to justify further clinical testing of the product. Under this FOA, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product. The data collected should be used to fill gaps in scientific knowledge and provide the information necessary to develop a competitive full-scale clinical trial.Support will be provided for up to two years (R21 phase) for milestone-driven bioavailability and pharmacokinetic testing and assessment of the natural products biological signature or mechanism of action. Based on the results of the R21 phase, this may be followed by support of up to 3 years (R33 phase) of support for further clinical studies of the natural product. This FOA is not appropriate for support of randomized clinical trials to test or determine efficacy. Ultimately, this R21/R33 funding mechanism is intended to speed the translation of emerging basic science findings about natural products into clinical pilot testing to determine whether continued clinical research is warranted. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AT-16-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AT-16-001 |
| Funding Opportunity Title: | Phased Innovation Award for Exploratory Clinical Trials of Natural Products in NCCIH High Priority Research Topics (R21/R33) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.213 — Research and Training in Complementary and Alternative Medicine |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 09, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Jun 22, 2015 |
| Archive Date: | Sep 04, 2015 |
| Estimated Total Program Funding: | $1,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) County governments For profit organizations other than small businesses Public housing authorities/Indian housing authorities Private institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Public and State controlled institutions of higher education State governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this funding opportunity is to support pilot testing of natural products (i.e., botanicals, dietary supplements, and probiotics), which have sufficient early-stage data to justify further clinical testing of the product. Under this FOA, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product. The data collected should be used to fill gaps in scientific knowledge and provide the information necessary to develop a competitive full-scale clinical trial.
Support will be provided for up to two years (R21 phase) for milestone-driven bioavailability and pharmacokinetic testing and assessment of the natural products biological signature or mechanism of action. Based on the results of the R21 phase, this may be followed by support of up to 3 years (R33 phase) of support for further clinical studies of the natural product. This FOA is not appropriate for support of randomized clinical trials to test or determine efficacy. Ultimately, this R21/R33 funding mechanism is intended to speed the translation of emerging basic science findings about natural products into clinical pilot testing to determine whether continued clinical research is warranted. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AT-16-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00213644 | May 22, 2015 | Aug 04, 2015 | View |
Package 1
Mandatory forms
273330 RR_SF424_2_0-2.0.pdf
273330 PHS398_ResearchPlan_2_0-2.0.pdf
273330 PHS398_CoverPageSupplement_2_0-2.0.pdf
273330 RR_Budget_1_3-1.3.pdf
273330 RR_KeyPersonExpanded_2_0-2.0.pdf
273330 RR_OtherProjectInfo_1_3-1.3.pdf
273330 PerformanceSite_2_0-2.0.pdf
Optional forms
273330 PlannedReport-1.0.pdf
273330 PHS398_CumulativeInclusionReport-1.0.pdf
273330 RR_SubawardBudget30_1_3-1.3.pdf
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