The National Cancer Institute (NCI) and Office of Dietary Supplements (ODS) offer this grant (R01) to advance understanding of how bioactive food components and combinations prevent cancer. This grant addresses the under-investigated interactions among dietary compounds, encouraging research on multiple components or intact foods at physiologically relevant concentrations. Applicants should employ new high-throughput genomic, epigenomic, proteomic, and metabolomic technologies to prioritize molecular targets. Research can focus on various sites of action, including carcinogen metabolism, DNA repair, cell proliferation, and inflammation, evaluating multiple targets or processes to identify key mechanisms driving phenotypic changes. The goal is to optimize cancer prevention, minimize toxicity, and inform dietary strategies to reduce cancer risk or modify tumor behavior.
Opportunity ID: 50372
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-10-035 |
| Funding Opportunity Title: | Prioritizing Molecular Targets for Cancer Prevention with Nutritional Combinations (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 24, 2009 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jan 07, 2013 |
| Current Closing Date for Applications: | Jan 07, 2013 |
| Archive Date: | Feb 07, 2013 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Small businesses For profit organizations other than small businesses Public and State controlled institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This Funding Opportunity Announcement (FOA), issued by the National Cancer Institute (NCI), and the Office of Dietary Supplements (ODS), of the National Institutes of Health (NIH), invites research applications to enhance our understanding about the dynamic interrelationship that exists between bioactive food components (and/or combinations thereof) and cancer prevention. Although much evidence exists that dietary components are linked to cancer prevention, the interactions among dietary bioactive compounds and food combinations remains under-investigated. Applications are encouraged to consider either multiple dietary bioactive components, intact foods or multiple foods utilizing physiologically relevant concentrations of the agents. New genetic technologies may be employed to study the impact of dietary components on complex cellular and molecular networks, as part of the effort to better understand the basis for the multifaceted interactions of food components with cancer prevention mechanisms. Specifically, applications that apply new high-throughput genomic, epigenomic, proteomic, and metabolomic technologies to prioritize molecular targets of dietary components are highly encouraged. The sites of action that may be evaluated include carcinogen metabolism, DNA repair, cell proliferation, apoptosis, differentiation, hormonal regulation, energetics, inflammation, and/or angiogenesis. In addition, applications should either evaluate multiple molecular targets within a cancer process or multiple processes in order to prioritize which process(es) is/are most involved in bringing about a phenotypic change. It is hoped that advances in this area may assist in optimizing cancer prevention while minimizing potential toxicity due to food components. The resulting information will help define which foods or food components should be considered in isolation or in combination when developing dietary strategies to reduce cancer risk and/or modify tumor behavior. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-10-035.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B | Use for submissions intended for due dates of January 25, 2010 and beyond | PKG00014735 | Jan 05, 2010 | Oct 14, 2010 | View | |
| ADOBE-FORMS-B1 | Supersedes ADOBE-FORMS-B | PKG00021872 | Oct 14, 2010 | Jan 07, 2013 | View |
Package 1
Mandatory forms
50372 RR_SF424_1_2-1.2.pdf
50372 PerformanceSite_1_3-1.3.pdf
50372 RR_OtherProjectInfo_1_2-1.2.pdf
50372 RR_KeyPersonExpanded_1_2-1.2.pdf
50372 PHS398_CoverPageSupplement_1_4-1.4.pdf
50372 PHS398_ResearchPlan_1_3-1.3.pdf
50372 PHS398_Checklist_1_3-1.3.pdf
Optional forms
50372 PHS_CoverLetter_1_2-1.2.pdf
50372 PHS398_ModularBudget-1.1.pdf
50372 RR_Budget-1.1.pdf
50372 RR_SubawardBudget-1.2.pdf
Package 2
Mandatory forms
50372 RR_SF424_1_2-1.2.pdf
50372 RR_OtherProjectInfo_1_3-1.3.pdf
50372 RR_KeyPersonExpanded_1_2-1.2.pdf
50372 PerformanceSite_1_4-1.4.pdf
50372 PHS398_ResearchPlan_1_3-1.3.pdf
50372 PHS398_CoverPageSupplement_1_4-1.4.pdf
50372 PHS398_Checklist_1_3-1.3.pdf
Optional forms
50372 RR_Budget-1.1.pdf
50372 RR_SubawardBudget-1.2.pdf
50372 PHS_CoverLetter_1_2-1.2.pdf
50372 PHS398_ModularBudget-1.1.pdf
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