This National Cancer Institute (NCI) and National Center for Complementary and Alternative Medicine (NCCAM) grant seeks applications to characterize how microbially generated dietary metabolites affect host cell biology. The goal is to understand their molecular mechanisms, particularly concerning cell proliferative/apoptotic responses, cytokine production, and immunomodulatory effects. The grant also supports human intervention studies to identify racial/ethnic variability in metabolite production and assess their efficacy in cancer prevention. This research is crucial for understanding the role of diet in cancer etiology, prevention, and health disparities, informing tailored dietary recommendations. The program promotes interdisciplinary collaboration, requiring multiple principal investigators with expertise in fields like microbiology, nutrition, and cancer biology. Awardees must attend annual meetings with NIH personnel.
Opportunity ID: 78853
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-11-152 |
| Funding Opportunity Title: | The Role of Microbial Metabolites in Cancer Prevention and Etiology (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.213 — Research and Training in Complementary and Alternative Medicine |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 15, 2011 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 15, 2012 |
| Current Closing Date for Applications: | Nov 15, 2012 |
| Archive Date: | Dec 16, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Foreign (non-U.S.) components on applications submitted by U.S. Organizations are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) issued by the National Cancer Institute (NCI), and the National Center for Complementary and Alternative Medicine, (NCCAM), at the National Institutes of Health, encourages the submission of grant applications that characterize the effects of microbially generated metabolites of dietary components on host cell biology. Specifically, this FOA seeks to characterize microbially generated metabolites and better understand their molecular mechanisms of action that affect host cell proliferative/apoptotic responses, cytokine production, inflammatory and immunomodulatory effects. This FOA will also encourage the conduct of human intervention studies that identify inter-individual variability among various racial and ethnic groups in the production of bacterial metabolites and determine their efficacy in cancer prevention. This research is necessary to better understand the role of dietary components in cancer etiology, prevention, and cancer health disparities to identify who might benefit from specific dietary recommendations and who might be placed at risk. One of the goals of this program will be to facilitate interdisciplinary collaborations among scientists engaged in nutrition, cancer prevention, cancer cell biology research, and cancer disparities research with those conducting studies with gut microorganisms. All applications must include multiple principle investigators with different areas of expertise such as microbiology, nutrition, cancer biology, analytical chemistry, or genetics. In addition, all investigators will be required to attend annual meetings with NIH personnel. Investigators may use either clinical or preclinical approaches. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-11-152.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B1 | ADOBE-FORMS-B1 | PKG00040210 | Oct 15, 2011 | Nov 15, 2012 | View |
Package 1
Mandatory forms
78853 RR_SF424_1_2-1.2.pdf
78853 RR_OtherProjectInfo_1_3-1.3.pdf
78853 RR_KeyPersonExpanded_1_2-1.2.pdf
78853 PerformanceSite_1_4-1.4.pdf
78853 PHS398_ResearchPlan_1_3-1.3.pdf
78853 PHS398_CoverPageSupplement_1_4-1.4.pdf
78853 PHS398_Checklist_1_3-1.3.pdf
Optional forms
78853 RR_Budget-1.1.pdf
78853 RR_SubawardBudget-1.2.pdf
78853 PHS_CoverLetter_1_2-1.2.pdf
78853 PHS398_ModularBudget-1.1.pdf
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