The National Cancer Institute is offering the PDXNet Data Commons and Coordinating Center (PDCCC) Grant to establish a central hub for the PDX Development and Trial Centers Research Network. This grant aims to support collaborative efforts in developing and testing targeted therapeutic agents using patient-derived models, furthering the field of cancer precision medicine. The PDCCC will play a key role in coordinating research activities and analyzing data within the PDXNet, ultimately leading to advancements in the clinical evaluation of novel drug combinations for cancer treatment.
Opportunity ID: 290482
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-CA-17-004 |
| Funding Opportunity Title: | PDX Data Commons and Coordinating Center (PDCCC) for the PDX Development and Trial Centers Research Network (PDXNet) (U24) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 93.394 — Cancer Detection and Diagnosis Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 06, 2016 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Mar 03, 2017 |
| Current Closing Date for Applications: | Mar 03, 2017 |
| Archive Date: | Apr 03, 2017 |
| Estimated Total Program Funding: | $650,000 |
| Award Ceiling: | $650,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Small businesses County governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Special district governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities State governments City or township governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this funding opportunity announcement (FOA) is to establish a PDXNet Data Commons and Coordinating Center (PDCCC). PDCCC will interact with and coordinate with the PDX (Patient-Derived Xenograft) Development and Trial Centers Research Network (PDXNet) comprised of four PDX Development and Trial Centers (PDTCs, to be supported by companion FOA, RFA-CA-17-003) in a collaborative network. The PDXNet is a National Cancer Institute (NCI) program established to coordinate collaborative, large-scale development and pre-clinical testing of targeted therapeutic agents in patient-derived models to advance the vision of cancer precision medicine. The goals for PDTCs include: development of new PDX models and methods for preclinical testing of single agents and drug combinations; and using the newly established models as well as other existing well-characterized PDX models for studies of drug responses. The PDCCC will serve as the coordinating and data analysis center of the PDXNet. It is expected that the outcomes of PDXNet research will be particularly important for the prioritization of combinations of agents in the portfolio of NCI Investigational New Drugs (NCI-IND agents), which are evaluated clinically in the NCIs Experimental Therapeutic Clinical Trials Network (ETCTN). |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-17-004.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-D | Use for due dates on or after May 25, 2016 | PKG00229602 | Feb 03, 2017 | Mar 03, 2017 | View |
Package 1
Mandatory forms
290482 RR_SF424_2_0-2.0.pdf
290482 PHS398_CoverPageSupplement_3_0-3.0.pdf
290482 RR_OtherProjectInfo_1_3-1.3.pdf
290482 PerformanceSite_2_0-2.0.pdf
290482 RR_KeyPersonExpanded_2_0-2.0.pdf
290482 RR_Budget_1_3-1.3.pdf
290482 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
290482 RR_SubawardBudget30_1_3-1.3.pdf
290482 PHS_Inclusion_Enrollment_Report-1.0.pdf
290482 PHS_AssignmentRequestForm-1.0.pdf
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