The Neurological Research Department is offering this grant to advance the understanding of cellular and molecular mechanisms underlying the brain’s blood vessel responses to passive anti-beta-amyloid immunotherapy. This initiative aims to investigate how these responses lead to amyloid-related imaging abnormalities (ARIA). This grant is specifically for establishing knowledge of molecular mechanisms that can be targeted to protect the blood-brain barrier (BBB) and brain blood vessels. The ultimate purpose is to safeguard the brain during therapeutic interventions designed to target beta-amyloid, ensuring safer and more effective treatments for neurological conditions associated with amyloid pathology.
Opportunity ID: 346862
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-23-140 |
| Funding Opportunity Title: | Blood Brain Barrier Response to Antibodies Targeting Beta-Amyloid (R01 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 15, 2023 |
| Last Updated Date: | Mar 15, 2023 |
| Original Closing Date for Applications: | Jun 02, 2023 |
| Current Closing Date for Applications: | Jun 02, 2023 |
| Archive Date: | Jul 08, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts For profit organizations other than small businesses County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Small businesses Public housing authorities/Indian housing authorities Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This initiative is designed to promote discovery of cellular and molecular mechanisms that underlie brain blood vessels responses to passive anti-beta-amyloid immunotherapy that result in amyloid-related imaging abnormalities (ARIA). The goal is to establish an understanding of molecular mechanisms that can be targeted to protect the blood brain barrier (BBB), and thus the brain blood vessels, during therapeutic interventions that target beta-amyloid. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-23-140.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 346862 Full Announcement-PAR-23-140 -> PAR-23-140-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00280551 | May 02, 2023 | Jun 02, 2023 | View |
Package 1
Mandatory forms
346862 RR_SF424_5_0-5.0.pdf
346862 PHS398_CoverPageSupplement_5_0-5.0.pdf
346862 RR_OtherProjectInfo_1_4-1.4.pdf
346862 PerformanceSite_4_0-4.0.pdf
346862 RR_KeyPersonExpanded_4_0-4.0.pdf
346862 PHS398_ResearchPlan_5_0-5.0.pdf
346862 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
346862 RR_Budget_3_0-3.0.pdf
346862 RR_SubawardBudget30_3_0-3.0.pdf
346862 PHS398_ModularBudget_1_2-1.2.pdf
346862 PHS_AssignmentRequestForm_3_0-3.0.pdf
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