This grant opportunity aims to foster a deeper mechanistic understanding of TDP-43 proteinopathies and their impact on clinical outcomes. It seeks to establish causal relationships between TDP-43 pathology and various phenotypic manifestations, exploring the intricate interactions between TDP-43 and other co-pathologies, such as TMEM106B. The funding supports comprehensive comparative studies across different TDP-43 proteinopathies, including LATE (with or without Alzheimer’s disease neuropathological change), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS). Research areas encompass mechanistic, molecular, structural, cellular, genetic, multi-omic, anatomical, and neuropathological analyses, striving to uncover distinct and overlapping mechanisms underlying these complex neurodegenerative conditions. The ultimate goal is to advance knowledge crucial for therapeutic development.
Opportunity ID: 348314
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-23-212 |
| Funding Opportunity Title: | Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs (R01 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | May 23, 2023 |
| Last Updated Date: | May 23, 2023 |
| Original Closing Date for Applications: | Oct 04, 2023 |
| Current Closing Date for Applications: | Oct 04, 2023 |
| Archive Date: | Nov 09, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses Small businesses Independent school districts State governments Special district governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This FOA would support establishing deeper mechanistic insight and causal relationships between TDP-43 pathology and phenotypic outcomes, as well as mechanistic interactions between TDP-43 and other co-pathologies, such TMEM106B. Additionally, it would include comparisons (including mechanistic, molecular, structural, cellular, genetic, -omic, anatomical, neuropathological, etc.) between TDP-43 proteinopathies, including LATE, with or without AD-NC, and FTD and/or ALS. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-23-212.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 348314 Full Announcement-PAR-23-212 -> PAR-23-212-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00281831 | Sep 04, 2023 | Oct 04, 2023 | View |
Package 1
Mandatory forms
348314 RR_SF424_5_0-5.0.pdf
348314 PHS398_CoverPageSupplement_5_0-5.0.pdf
348314 RR_OtherProjectInfo_1_4-1.4.pdf
348314 PerformanceSite_4_0-4.0.pdf
348314 RR_KeyPersonExpanded_4_0-4.0.pdf
348314 PHS398_ResearchPlan_5_0-5.0.pdf
348314 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
348314 RR_Budget_3_0-3.0.pdf
348314 RR_SubawardBudget30_3_0-3.0.pdf
348314 PHS398_ModularBudget_1_2-1.2.pdf
348314 PHS_AssignmentRequestForm_3_0-3.0.pdf
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