The neuroscience department is offering a grant to support the development and evaluation of neurophysiological assays aimed at bridging the gap between preclinical and clinical research for mental disorders. This grant seeks to improve the efficiency of therapeutic development by identifying and optimizing measures that can be assessed in both animals and humans. Through partnerships with neuroscientists, the grant aims to establish reliable assays for evaluating new drug and device therapies, ultimately accelerating the discovery of more effective treatments for mental health conditions.
Opportunity ID: 271352
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-16-220 |
| Funding Opportunity Title: | Novel Assays to Address Translational Gaps in Treatment Development (UH2/UH3) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 12, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Apr 03, 2015 |
| Current Closing Date for Applications: | Apr 03, 2015 |
| Archive Date: | May 04, 2015 |
| Estimated Total Program Funding: | $1,500,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses For profit organizations other than small businesses Native American tribal governments (Federally recognized) State governments Special district governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) County governments City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The overall goal of this initiative is to identify, optimize, and evaluate measures of neurophysiological processes that are disrupted within or across mental disorders and which can be assessed in animals and humans. The goal is to support further development of these measures as assays for evaluating potential new drug and device therapies and their targets. Data will also reveal assay measures where the performance between preclinical species and humans is dissimilar, thus establishing a firm basis for limiting speculative extrapolations of preclinical findings. Ultimately, the goal of this FOA is to improve the efficiency of the therapeutic development process by addressing inconsistencies between the preclinical screening pipeline and clinical evaluation of new treatment candidates and thereby hasten the development of more effective treatments for mental disorders.
The objectives of the FOA will be accomplished by supporting partnerships among basic and translational neuroscientists who are committed to advancing the discovery of physiological measures as tools for target validation and therapeutic development. Groups will be tasked with building a target-engagement-linked-to-functional-brain-effect suite of assays with potential to translate from animals to humans and thus serve as a basis for selecting preclinical treatment candidates for further development and clinical testing. Towards this goal, the FOA will support development, optimization and evaluation of brain based assays in both preclinical species and in healthy humans and the evaluation of assay performance in response to carefully selected chemical, physiological, or behavioral manipulations. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-16-220.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00211624 | Mar 03, 2015 | Apr 03, 2015 | View |
Package 1
Mandatory forms
271352 RR_SF424_2_0-2.0.pdf
271352 PHS398_ResearchPlan_2_0-2.0.pdf
271352 PHS398_CoverPageSupplement_2_0-2.0.pdf
271352 RR_Budget_1_3-1.3.pdf
271352 RR_KeyPersonExpanded_2_0-2.0.pdf
271352 RR_OtherProjectInfo_1_3-1.3.pdf
271352 PerformanceSite_2_0-2.0.pdf
Optional forms
271352 PlannedReport-1.0.pdf
271352 PHS398_CumulativeInclusionReport-1.0.pdf
271352 RR_SubawardBudget30_1_3-1.3.pdf
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