This grant is for supporting in-depth mechanistic investigations into Alzheimer’s Disease and Related Dementias (ADRD) involving multiple etiologies. The focus is on understanding how at least two co-pathologies (e.g., tau, alpha-synuclein, TDP-43, TMEM106B, or vascular issues), along with optional risk factors, interact at cellular and molecular levels. The aim is to uncover why these multi-proteinopathy interactions accelerate neurodegeneration and worsen phenotypic outcomes. Proposed studies should meticulously examine co-pathology interactions across diverse brain regions, over time, within specific cell populations, and through various intracellular dynamics. The research seeks to identify events, both upstream and downstream of protein aggregation, that lead to more severe disease manifestations.
Opportunity ID: 352213
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-24-147 |
| Funding Opportunity Title: | Mechanistic Investigations into ADRD Multiple Etiology Dementias (R01 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 06, 2024 |
| Last Updated Date: | Feb 06, 2024 |
| Original Closing Date for Applications: | Oct 04, 2024 |
| Current Closing Date for Applications: | Oct 04, 2024 |
| Archive Date: | Nov 09, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses State governments Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Small businesses Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Independent school districts County governments Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This NOFO would support investigations with a minimum of two relevant co-pathologies (e.g., tau, alpha-synuclein, TDP-43, TMEM106B, vascular), with optional risk factors and co-morbidities, to identify cellular and molecular mechanisms of how/why multi-proteinopathy interactions drive worsening neurodegenerative processes and phenotypic outcomes. Studies should examine co-pathology cellular and molecular interactions across brain regions and time in proximate cell population, across various intracellular dynamics and localization, and upstream and downstream from aggregated protein states to determine what events lead to worse phenotypic outcomes. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-24-147.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 352213 Full Announcement-PAR-24-147 -> PAR-24-147-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00284734 | May 04, 2024 | Oct 04, 2024 | View |
Package 1
Mandatory forms
352213 RR_SF424_5_0-5.0.pdf
352213 PHS398_CoverPageSupplement_5_0-5.0.pdf
352213 RR_OtherProjectInfo_1_4-1.4.pdf
352213 PerformanceSite_4_0-4.0.pdf
352213 RR_KeyPersonExpanded_4_0-4.0.pdf
352213 PHS398_ResearchPlan_5_0-5.0.pdf
352213 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
352213 RR_Budget_3_0-3.0.pdf
352213 RR_SubawardBudget30_3_0-3.0.pdf
352213 PHS398_ModularBudget_1_2-1.2.pdf
352213 PHS_AssignmentRequestForm_3_0-3.0.pdf
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