This National Human Genome Research Institute (NHGRI) grant aims to establish Disease Study Sites (DSS) as part of a collaborative initiative. The purpose of this grant is to advance the application of multi-omic technologies to study health and disease across diverse populations. DSS will work with Omics Production and Data Coordination Centers to leverage clinical conditions, integrating multi-omics with phenotypic and environmental data, including social determinants of health. Awardees will explore molecular profiles, develop data harmonization methods, and create a multi-dimensional dataset accessible to the research community. Each DSS will propose a focused disease study, recruit participants, collect samples, and contribute to consortium-wide protocol development and data analysis. The primary goal is to validate and enhance generalizable multi-omic approaches for identifying meaningful biological changes related to health and disease.
Opportunity ID: 343373
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HG-22-008 |
| Funding Opportunity Title: | Multi-Omics for Health and Disease – Disease Study Sites (U01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Environment Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 07, 2022 |
| Last Updated Date: | Sep 07, 2022 |
| Original Closing Date for Applications: | Nov 18, 2022 |
| Current Closing Date for Applications: | Nov 18, 2022 |
| Archive Date: | Dec 24, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities Special district governments State governments Small businesses City or township governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Public and State controlled institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) County governments Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this Funding Opportunity Announcement (FOA) is to establish Disease Study Sites (DSS) that will be part of a collaborative initiative to advance the application of multi-omic technologies to study health and disease in diverse populations. Together with the Omics Production Centers (RFA-HG-22-009) and the Data Analysis and Coordination Center (RFA-HG-22-010), the Disease Study Sites will leverage clinical conditions where multi-omic approaches are expected to be most informative to: 1) explore the use of multi-omics, integrated with phenotypic and environmental exposure data, including social determinants of health (SDOH), to detect and assess molecular profiles associated with healthy and disease states; 2) develop generalizable data harmonization, integration, and analysis methods, as well as best practices and standards for the optimal application of multi-omics; and 3) create a multi-dimensional dataset that is available to the research community. Each DSS will be primarily responsible for proposing a study focused on a disease area for which integrative multi-omics could be used to define associations with healthy and disease states and to detect changes over time. Each DSS will utilize effective strategies to enroll and consent participants, collect phenotypic and environmental exposure data, collect samples and measures over time, and contribute to consortium-wide protocol development, data analysis, methods development, and the production of the multi-dimensional dataset. While this program may provide some insights into disease etiology, its primary goal is to validate and enhance generalizable multi-omic approaches to identify meaningful biological changes related to health and disease. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-HG-22-008.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 343373 Full Announcement-RFA-HG-22-008 -> RFA-HG-22-008-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00276656 | Oct 18, 2022 | Nov 18, 2022 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00277983 | Nov 04, 2022 | Nov 18, 2022 | View |
Package 1
Mandatory forms
343373 RR_SF424_5_0-5.0.pdf
343373 PHS398_CoverPageSupplement_5_0-5.0.pdf
343373 RR_OtherProjectInfo_1_4-1.4.pdf
343373 PerformanceSite_4_0-4.0.pdf
343373 RR_KeyPersonExpanded_4_0-4.0.pdf
343373 PHS398_ResearchPlan_4_0-4.0.pdf
343373 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343373 RR_Budget_3_0-3.0.pdf
343373 RR_SubawardBudget30_3_0-3.0.pdf
343373 PHS398_ModularBudget_1_2-1.2.pdf
343373 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
343373 RR_SF424_5_0-5.0.pdf
343373 PHS398_CoverPageSupplement_5_0-5.0.pdf
343373 RR_OtherProjectInfo_1_4-1.4.pdf
343373 PerformanceSite_4_0-4.0.pdf
343373 RR_KeyPersonExpanded_4_0-4.0.pdf
343373 PHS398_ResearchPlan_5_0-5.0.pdf
343373 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343373 RR_Budget_3_0-3.0.pdf
343373 RR_SubawardBudget30_3_0-3.0.pdf
343373 PHS398_ModularBudget_1_2-1.2.pdf
343373 PHS_AssignmentRequestForm_3_0-3.0.pdf
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