This National Heart, Lung, and Blood Institute (NHLBI) grant seeks applications for the Clinical Coordinating Center (CCC) for its Severe Asthma Research Program (SARP). This program aims to address the complexity and heterogeneity of severe asthma, which impedes effective treatments due to unknown underlying mechanisms and sub-phenotype stability. SARP will develop a new paradigm by longitudinally defining severe asthma at the molecular and cellular level in children and adults. Investigators will characterize developmental phenotypes, elucidate pathobiology, and identify research questions for a shared longitudinal protocol across participating centers. The overall goal is to enable prediction of phenotype stability and pharmacologic response, and to identify novel, disease-modifying treatment targets. This multidisciplinary collaborative research will provide an integrated understanding of severe asthma sub-phenotypes, focusing on mechanistic approaches rather than cross-sectional studies or therapeutic trials.
Opportunity ID: 54806
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-11-030 |
| Funding Opportunity Title: | Clinical Coordinating Center for the Severe Asthma Research Program (SARP) (U10) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.838 — Lung Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | May 26, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Oct 15, 2010 |
| Current Closing Date for Applications: | Oct 15, 2010 |
| Archive Date: | Nov 15, 2010 |
| Estimated Total Program Funding: | $31,500,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments Independent school districts Private institutions of higher education Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education City or township governments County governments Special district governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. The National Heart, Lung, and Blood Institute invites applications to participate as the Clinical Coordinating Center (CCC) in the NHLBI Severe Asthma Research Program (SARP). Accumulating evidence suggests that severe asthma is complex and phenotypically heterogeneous across individuals and time. Not knowing the underlying mechanisms and stability of these sub-phenotypes impedes the development of effective treatments and management strategies. This phase of SARP will develop a new paradigm for understanding severe asthma and its sub-phenotypes, in children and adults, by defining disease at the molecular and cellular level longitudinally. The new SARP investigators will use mechanistic and evoked phenotype approaches to characterize developmental molecular, cellular and physiologic phenotypes in children and adults with mild to severe asthma and to further elucidate the evolving pathobiology and pathogenesis of severe asthma and its sub-phenotypes. SARP investigators will work together to identify the important research questions that require a shared longitudinal protocol which will be conducted across all participating centers and which will include common information on all SARP participants. In addition, SARP investigators will identify research questions separate from those proposed for the shared longitudinal protocol which may be investigated using the shared protocol or in participants from one or more centers. The overall aim is to enable prediction of phenotype stability / fluctuation and pharmacologic response, and to identify novel, disease-modifying targets for treatment. This longitudinal mechanistic research approach will provide integrated understanding of the fixed and variable molecular, cellular, and pathophysiologic underpinnings of severe asthma sub-phenotypes. Cross-sectional studies or therapeutic trials are not the intent of this FOA. This program will require multidisciplinary research collaboration and partnerships between asthma clinician-scientists and scientists with expertise in areas such as immunology, pulmonary physiology, molecular genetics, molecular phenotyping, imaging, and bioinformatics. SARP will consist of up to six Clinical Centers, a Clinical Coordinating Center, and a Steering Committee. This FOA solicits applications for the Clinical Coordinating Center and runs parallel with a separate FOA that solicits applications for Clinical Centers (see RFA-HL-11-018) |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-11-030.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
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