This National Institute of Allergy and Infectious Diseases (NIAID) cooperative research grant supports large-scale, broad-scope genomic studies in clinical transplantation of solid organs, tissues, and cells. The program’s purpose is to identify and characterize gene polymorphisms and expression patterns. It aims to correlate these patterns with transplantation outcomes, define immune responses linked to acute and chronic graft rejection, and predict patient responses to immunosuppression to allow for tailored therapy. Additionally, this grant seeks to elucidate the genetic basis of variability in graft survival among different populations or individuals. The long-term goal is to understand the genetic basis of immune-mediated graft rejection and transplant outcome differences, providing a foundation for developing more effective treatments to improve long-term graft survival and enhance transplant patient quality of life.
Opportunity ID: 56103
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-10-019 |
| Funding Opportunity Title: | Genomics of Transplantation Cooperative Research Program (U01, U19) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy, Immunology and Transplantation Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 23, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 19, 2010 |
| Current Closing Date for Applications: | Nov 19, 2010 |
| Archive Date: | Dec 20, 2010 |
| Estimated Total Program Funding: | $4,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Native American tribal governments (Federally recognized) Independent school districts Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities City or township governments County governments Special district governments State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. The National Institute of Allergy and Infectious Diseases (NIAID) invites new or renewal applications from single institutions or consortia of institutions to participate in a cooperative interdisciplinary research program for large-scale, broad-scope genomic studies in clinical transplantation of solid organ, tissue, and cells. The goals of this program are to identify and characterize gene polymorphisms and gene expression patterns that: (1) correlate with and/or predict transplantation outcomes; (2) define immune responses relating to the onset and severity of acute and chronic graft rejection; (3) predict responses to immunosuppression to allow tailoring of therapy; and (4) elucidate the genetic basis of variability in graft survival between populations or individuals. The long-term goal of the program is to understand the genetic basis of immune-mediated graft rejection and differences in transplant outcomes to provide a rational basis for developing more effective treatments to improve long-term graft survival and provide a better quality-of-life for transplant patients. Mechanism of Support. This Funding Opportunity Announcement (FOA) will utilize the single project (U01), and multi-project (U19) Cooperative Agreement award mechanism. Funds Available and Anticipated Number of Awards. The NIAID anticipates that approximately $4 million total costs will be available in FY 2011 to fund two to four new or renewal U01 and/or U19 awards. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-10-019.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
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