This NIAID grant is for developing a comprehensive understanding of innate or adaptive immune responses to infection and vaccination against pathogenic microbes, particularly NIAID Emerging/Re-emerging Pathogens, using a systems biology approach. The initiative supports quantitative analyses to identify and measure dynamic networks regulating immune responses. Research will be based on genome-wide screens of mutant mice to identify key regulatory immune response genes, complemented by detailed genomics, proteomics, computational biology, and bioinformatics, focusing on transcriptional regulation and signaling. A subset of newly discovered murine genes will be analyzed in human correlation studies.
Opportunity ID: 82353
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-11-017 |
| Funding Opportunity Title: | Systems Approach to Immunity and Inflammation (U19) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy, Immunology and Transplantation Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 25, 2011 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Aug 30, 2011 |
| Current Closing Date for Applications: | Aug 30, 2011 |
| Archive Date: | Sep 30, 2011 |
| Estimated Total Program Funding: | $7,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Public and State controlled institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Native American tribal governments (Federally recognized) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Small businesses Private institutions of higher education City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Foreign (non-U.S.) components of U.S. Organizations are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The primary objective of the program is to use a systems biology approach to develop a comprehensive understanding of innate or adaptive immune responses to infection with and/or vaccination against one or more pathogenic microbes, with a focus on NIAID Emerging/Re-emerging Pathogens of concern to human health. The initiative will support quantitative analyses that will identify and measure dynamic networks regulating immune responses. The basis of the research program will be genome wide screens of mutant mice for identification of key regulatory immune response genes. The studies will be complemented by detailed genomics, proteomics, computational biology and bioinformatics approaches that focus on transcriptional regulation and signaling mechanisms. Investigators will analyze a subset of the newly discovered murine immune regulatory genes in human correlation studies. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-11-017.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
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