The National Institute of Child Health and Human Development (NICHD) and National Institute of Mental Health (NIMH) offer an R21 grant. This grant funds pharmacokinetic research in pediatric HIV/TB co-infection, evaluating anti-tuberculosis (anti-TB) drug pharmacokinetics and interactions with anti-HIV medications. Addressing pediatric TB management complexities, this funding supports projects defining appropriate anti-TB dosing for HIV-infected children. It aims to optimize pediatric TB/HIV co-infection management, including assessing central nervous system (CNS) penetration of anti-TB agents during antiretroviral therapy. This initiative generates vital knowledge, improving treatment outcomes for co-infected children.
Opportunity ID: 52451
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HD-09-016 |
| Funding Opportunity Title: | Pharmacokinetic Research in Pediatric HIV/TB Co-Infection (R21) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 04, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Aug 24, 2010 |
| Current Closing Date for Applications: | Aug 24, 2010 |
| Archive Date: | Sep 24, 2010 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts For profit organizations other than small businesses Public and State controlled institutions of higher education Small businesses State governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments County governments Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This Funding Opportunity Announcement (FOA), issued by the National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH), encourages Exploratory/Developmental Research Grant Award (R21) applications from institutions/organizations that propose to evaluate the pharmacokinetics of anti-tuberculosis (anti-TB) drugs and pharmacokinetic drug interactions between anti-TB drugs and anti-HIV medications in children with HIV/TB co-infection. Research in this area lags far behind that in adults due to the many challenges surrounding the diagnosis and management of TB disease in children. Research related to the treatment of TB in the context of pediatric HIV/TB co-infection is urgently needed. This FOA will support investigator-initiated grants to define appropriate dosing of anti-TB agents in HIV-infected children and will generate knowledge leading to the optimization of management of TB/HIV co-infection in children, including the management of central nervous system (CNS) involvement with TB through the evaluation of CNS penetration of anti-TB agents in the context of antiretroviral therapy. Mechanism of Support. This FOA will utilize the NIH Exploratory/Developmental Research Grant (R21) award mechanism and is issued in parallel with an FOA of identical scientific scope, RFA-HD-09-015 that encourages applications under the R01 grant mechanism. Funds Available and Anticipated Number of Awards. The NICHD intends to commit $250,000 (total costs), and NIMH intends to commit $150,000 (total costs) in FY 2010 to support one to two meritorious applications. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-09-016.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B | Use for submissions intended for due dates of January 25, 2010 and beyond | PKG00016905 | Jul 24, 2010 | Aug 24, 2010 | View |
Package 1
Mandatory forms
52451 RR_SF424_1_2-1.2.pdf
52451 PerformanceSite_1_3-1.3.pdf
52451 RR_OtherProjectInfo_1_2-1.2.pdf
52451 RR_KeyPersonExpanded_1_2-1.2.pdf
52451 PHS398_CoverPageSupplement_1_4-1.4.pdf
52451 PHS398_ResearchPlan_1_3-1.3.pdf
52451 PHS398_Checklist_1_3-1.3.pdf
Optional forms
52451 PHS_CoverLetter_1_2-1.2.pdf
52451 PHS398_ModularBudget-1.1.pdf
52451 RR_Budget-1.1.pdf
52451 RR_SubawardBudget-1.2.pdf
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