This grant aims to address significant gaps hindering the effective use of decentralized clinical trials (DCT) for Substance Use Disorder (SUD) research. Current physiological sensors are underutilized and require further validation for SUD contexts. A critical need exists for wearable or home-use detection devices capable of measuring substances of interest, including methadone, buprenorphine, their metabolites, and illicit drugs, which are currently unavailable or not designed for diagnostics/treatment. Most existing measurement devices are laboratory-based and lack standard software interfaces for seamless data transmission to study centers. This initiative seeks innovative solutions to develop and validate new tools and technologies that overcome these limitations, thereby enhancing the feasibility and impact of DCTs in the substance use area.
Opportunity ID: 350720
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DA-25-051 |
| Funding Opportunity Title: | Tools for Decentralized Clinical Trials for Substance Use Disorder (R41/R42 Clinical Trials Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Abuse and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 25, 2023 |
| Last Updated Date: | Oct 25, 2023 |
| Original Closing Date for Applications: | Mar 14, 2024 |
| Current Closing Date for Applications: | Mar 14, 2024 |
| Archive Date: | Apr 19, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $1,972,828 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | There are gaps that prevent the utilization of decentralized clinical trials (DCT) in substance use area. The existing sensors for physiological measurement are rarely used and may need further validation. There are no wearable or home-use detection devices on the market capable to measure substances of interest (e.g., methadone, buprenorphine, their metabolites, as well as the spectrum of illicit drugs). The devices in development are not intended for diagnostics or treatment. Most of the devices are intended for laboratory use. Most of the devices do not have standard software interface through which the devices can transmit the data to the study center. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-051.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 350720 Full Announcement-RFA-DA-25-051 -> RFA-DA-25-051-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00283603 | Feb 14, 2024 | Mar 14, 2024 | View |
Package 1
Mandatory forms
350720 RR_SF424_5_0-5.0.pdf
350720 PHS398_CoverPageSupplement_5_0-5.0.pdf
350720 RR_OtherProjectInfo_1_4-1.4.pdf
350720 PerformanceSite_4_0-4.0.pdf
350720 RR_KeyPersonExpanded_4_0-4.0.pdf
350720 RR_Budget_3_0-3.0.pdf
350720 RR_SubawardBudget30_3_0-3.0.pdf
350720 PHS398_ResearchPlan_5_0-5.0.pdf
350720 SBIR_STTR_Information_3_0-3.0.pdf
350720 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
350720 PHS_AssignmentRequestForm_3_0-3.0.pdf
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