The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) are offering this grant to support research addressing the complexities of congenital obstructive uropathy (COU). This condition is a leading cause of chronic kidney disease and end-stage renal disease in infants and children, yet its underlying mechanisms, effective detection, and optimal treatment strategies remain poorly understood. This grant is for advancing scientific and clinical understanding by encouraging studies on objective prognostic markers, genetic determinants, reliable animal models, and the long-term efficacy of various interventions for COU, aiming to resolve significant scientific and clinical uncertainties.
Opportunity ID: 48287
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-09-226 |
| Funding Opportunity Title: | Basic and Clinical Studies of Congenital Urinary Tract Obstruction (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Food and Nutrition Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 02, 2009 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Sep 07, 2012 |
| Current Closing Date for Applications: | Sep 07, 2012 |
| Archive Date: | Oct 08, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts State governments County governments Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments For profit organizations other than small businesses Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This Program Announcement is sponsored by the NIDDK and the NICHD. Congenital obstructive uropathy is one of the major causes of chronic kidney disease and end stage renal disease (ESRD) in infants and children. The pathogenesis of this disorder, however, remains poorly understood. Many controversies and clinical uncertainties exist in the detection, prognosis, and effective treatment strategies for this condition. The impact of early fetal detection and neonatal intervention, the long-term effects of watchful waiting and the various surgical interventions have not been well studied and documented. There is also no consensus on the indications for, or ideal timing of surgical intervention. The purpose of this funding opportunity is to address the numerous scientific and clinical uncertainties related to the development, treatment and prognosis of congenital obstructive uropathy, by encouraging and facilitating research in diverse areas. These areas include: the development of objective prognostic markers; the genetic determinants of this congenital disorder; the development of reliable animal models of the disorder; and, evaluation of the long-term effectiveness of various treatment strategies. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) grant. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-09-226.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B1 | Supersedes ADOBE-FORMS-B | PKG00021815 | Oct 13, 2010 | Sep 07, 2012 | View | |
| ADOBE-FORMS-A | Adobe-Forms-A | PKG00012908 | Sep 05, 2009 | Feb 20, 2010 | View | |
| ADOBE-FORMS-B | Use for submissions intended for due dates of January 25, 2010 and beyond | PKG00014962 | Dec 21, 2009 | Oct 13, 2010 | View |
Package 1
Mandatory forms
48287 RR_SF424_1_2-1.2.pdf
48287 RR_OtherProjectInfo_1_3-1.3.pdf
48287 RR_KeyPersonExpanded_1_2-1.2.pdf
48287 PerformanceSite_1_4-1.4.pdf
48287 PHS398_ResearchPlan_1_3-1.3.pdf
48287 PHS398_CoverPageSupplement_1_4-1.4.pdf
48287 PHS398_Checklist_1_3-1.3.pdf
Optional forms
48287 RR_Budget-1.1.pdf
48287 RR_SubawardBudget-1.2.pdf
48287 PHS_CoverLetter_1_2-1.2.pdf
48287 PHS398_ModularBudget-1.1.pdf
Package 2
Mandatory forms
48287 RR_SF424-1.1.pdf
48287 RR_KeyPersonExpanded-1.1.pdf
48287 RR_OtherProjectInfo-1.1.pdf
48287 RR_PerformanceSite-1.1.pdf
48287 PHS398_CoverPageSupplement-1.1.pdf
48287 PHS398_ResearchPlan-1.1.pdf
48287 PHS398_Checklist-1.1.pdf
Optional forms
48287 PHS398_CoverLetter-1.1.pdf
48287 PHS398_ModularBudget-1.1.pdf
48287 RR_Budget-1.1.pdf
48287 RR_SubawardBudget-1.2.pdf
Package 3
Mandatory forms
48287 RR_SF424_1_2-1.2.pdf
48287 PerformanceSite_1_3-1.3.pdf
48287 RR_OtherProjectInfo_1_2-1.2.pdf
48287 RR_KeyPersonExpanded_1_2-1.2.pdf
48287 PHS398_CoverPageSupplement_1_4-1.4.pdf
48287 PHS398_ResearchPlan_1_3-1.3.pdf
48287 PHS398_Checklist_1_3-1.3.pdf
Optional forms
48287 PHS_CoverLetter_1_2-1.2.pdf
48287 PHS398_ModularBudget-1.1.pdf
48287 RR_Budget-1.1.pdf
48287 RR_SubawardBudget-1.2.pdf
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