NIDDK is offering a grant opportunity for the Human Islet Research Network-Consortium on Human Islet Biomimetics (HIRN-CHIB) to develop a microphysiological system simulating interactions between human islets and immune cells to model Type 1 diabetes. The goal is to create an in vitro human disease model using T1D patient-derived islets and autologous immune components. HIRN-CHIB, part of HIRN, aims to understand beta cell loss in T1D and develop strategies to protect and replace functional beta cells.
Opportunity ID: 308124
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-18-011 |
| Funding Opportunity Title: | Human Islet Research Network – Consortium on Human Islet Biomimetics (HIRN-CHIB) (UG3/UH3 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 10, 2018 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Dec 11, 2018 |
| Current Closing Date for Applications: | Dec 11, 2018 |
| Archive Date: | Jan 16, 2019 |
| Estimated Total Program Funding: | $3,000,000 |
| Award Ceiling: | $750,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public housing authorities/Indian housing authorities City or township governments Public and State controlled institutions of higher education Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Special district governments For profit organizations other than small businesses Small businesses State governments Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This FOA invites new applications to participate in the Human Islet Research Network-Consortium on Human Islet Biomimetics (HIRN-CHIB). NIDDK will support the development of a microphysiological system (MPS) that allows the study of interactions between primary human islets or assembled islet spheroids (organoids made up of human beta/alpha/delta/other cells) and immune cells within a 3D microenvironment to mimic aspects of the autoimmune process and its regulation. The ultimate goal will be to create an in vitro human disease model(s) that could recapitulate some aspects of the complex pathophysiology of Type 1 diabetes (T1D), by using T1D patient-derived islets (created using induced pluripotent stem cells (iPSCs) combined with autologous immune components. CHIB is already part of HIRN, whose overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-18-011.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00244359 | Nov 11, 2018 | Dec 11, 2018 | View |
Package 1
Mandatory forms
308124 RR_SF424_2_0-2.0.pdf
308124 PHS398_CoverPageSupplement_4_0-4.0.pdf
308124 RR_OtherProjectInfo_1_4-1.4.pdf
308124 PerformanceSite_2_0-2.0.pdf
308124 RR_KeyPersonExpanded_2_0-2.0.pdf
308124 RR_Budget_1_4-1.4.pdf
308124 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
308124 RR_SubawardBudget30_1_4-1.4.pdf
308124 PHS_AssignmentRequestForm_2_0-2.0.pdf
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