The NIDDK is offering this single-source cooperative agreement to the University of Pennsylvania to continue the critical mission of the Human Pancreas Analysis Program for Type 1 Diabetes (HPAP-T1D). This grant aims to support a team with expertise in human pancreas physiology, immunology, tissue analysis, and data management. The primary objectives are to identify, collect, and thoroughly characterize pancreatic tissues and immune cells from individuals with type 1 diabetes, those at risk, and age-matched controls. Subsequently, the team will analyze, organize, and disseminate the resulting data through the existing PANC DB open-access resource. HPAP-T1D is a vital component of the Human Islet Research Network (HIRN), which seeks to understand beta cell loss in T1D and develop strategies to protect or replace functional human beta cell mass.
Opportunity ID: 354719
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-25-012 |
| Funding Opportunity Title: | Single Source for the Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 05, 2024 |
| Last Updated Date: | Jun 05, 2024 |
| Original Closing Date for Applications: | Oct 24, 2024 |
| Current Closing Date for Applications: | Oct 24, 2024 |
| Archive Date: | Nov 29, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $5,500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. See full Notice of Funding Opportunity for additional details on eligibility. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Notice of Funding Opportunity (NOFO) is a non-competitive funding opportunity intended to fund a single award. The NIDDK is announcing its intent to issue a single source cooperative agreement to the University of Pennsylvania to continue the mission of the existing Human Pancreas Analysis Program for Type 1 Diabetes (HPAP-T1D). This NOFO will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; immunology and autoimmunity; collection, processing and multimodal analysis of human pancreatic tissues and immune compartments; and biological database building, curation and management, that will be tasked to: 1) identify, collect and intensively characterize primary pancreatic tissues and immune cells from patients with type 1 diabetes (T1D) or at risk of developing the disease, as well as age-matched controls; and 2) analyze, organize and share the data resulting from the study of these tissues through the existing PANC DB open-access resource database. HPAP-T1D is a component of the Human Islet Research Network or HIRN. HIRN was created in 2014 to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional human beta cell mass. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-25-012.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 354719 Full Announcement-RFA-DK-25-012 -> RFA-DK-25-012-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00286860 | Sep 24, 2024 | Oct 24, 2024 | View |
Package 1
Mandatory forms
354719 RR_SF424_5_0-5.0.pdf
354719 PHS398_CoverPageSupplement_5_0-5.0.pdf
354719 RR_OtherProjectInfo_1_4-1.4.pdf
354719 PerformanceSite_4_0-4.0.pdf
354719 RR_KeyPersonExpanded_4_0-4.0.pdf
354719 PHS398_ResearchPlan_5_0-5.0.pdf
354719 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
354719 RR_Budget_3_0-3.0.pdf
354719 RR_SubawardBudget30_3_0-3.0.pdf
354719 PHS398_ModularBudget_1_2-1.2.pdf
354719 PHS_AssignmentRequestForm_3_0-3.0.pdf
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