The National Institute of Environmental Health Sciences (NIEHS) is offering this grant to encourage research into the mechanistic understanding of how environmental exposures influence gene expression. While NIEHS has invested significantly in identifying epigenetic signatures of exposure, there is a recognized gap in studies exploring the upstream proteins and processes involved in establishing these epigenetic marks. This grant is for researchers seeking to move beyond descriptive and correlative studies. The purpose is to foster enhanced mechanistic insights into how environmental exposures affect the proteins and functional genomic elements crucial for establishing and maintaining gene expression patterns and chromatin states, ultimately clarifying how toxicants impact gene regulation.
Opportunity ID: 194733
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-ES-12-008 |
| Funding Opportunity Title: | TaRGET I: Chromatin Structure, Genomics, and Transcriptional Responses to the Environment (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Environment Health |
| Category Explanation: | – |
| Expected Number of Awards: | 5 |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 23, 2012 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 19, 2012 |
| Current Closing Date for Applications: | Nov 19, 2012 |
| Archive Date: | Dec 20, 2012 |
| Estimated Total Program Funding: | $3,000,000 |
| Award Ceiling: | $400,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses City or township governments Special district governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts Native American tribal governments (Federally recognized) Private institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | In order to understand the mechanisms by which toxicants impact gene expression, it is necessary to better understand how exposure affects the proteins and processes upstream of DNA methylation and other epigenetic marks. The NIEHS has made a significant investment in research aimed at identifying epigenetic signatures of exposure, but the mechanistic studies aimed at identifying how these epigenetic marks are established are currently under-represented in our portfolio. The purpose of this FOA is to encourage research applications that will potentially move the field from descriptive and correlative studies to an enhanced mechanistic understanding of how environmental exposures affect the proteins and functional genomic elements involved in establishing and maintaining gene expression patterns and chromatin states. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-12-008.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B2 | Adobe-Forms-B2 | PKG00140410 | Oct 19, 2012 | Nov 19, 2012 | View |
Package 1
Mandatory forms
194733 RR_SF424_1_2-1.2.pdf
194733 PerformanceSite_1_4-1.4.pdf
194733 RR_OtherProjectInfo_1_3-1.3.pdf
194733 RR_KeyPersonExpanded_1_2-1.2.pdf
194733 PHS398_CoverPageSupplement_1_4-1.4.pdf
194733 PHS398_ResearchPlan_1_3-1.3.pdf
194733 PHS398_Checklist_1_3-1.3.pdf
Optional forms
194733 RR_SubawardBudget30-1.2.pdf
194733 PHS398_ModularBudget_1_2-1.2.pdf
194733 RR_Budget-1.1.pdf
194733 PHS_CoverLetter_1_2-1.2.pdf
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