The NIEHS offers the FRAMED grant to support research into how environmental exposures interact with functional RNA modifications and pathways. This grant aims to explore the impact of stressors on RNA modifications, potential associations with adverse health outcomes, and the development of biomarkers. By focusing on the understudied connection between environmental exposures and RNA modifications, this grant seeks to enhance our understanding of the link between exposures and complex human diseases. The NIEHS invites innovative research applications that combine toxicology principles with RNA modification expertise and utilize advanced technologies to investigate this emerging field.
Opportunity ID: 312763
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-ES-19-001 |
| Funding Opportunity Title: | Functional RNA Modifications Environment and Disease (FRAMED) (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Environment Health |
| Category Explanation: | – |
| Expected Number of Awards: | 5 |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 08, 2019 |
| Last Updated Date: | Feb 08, 2019 |
| Original Closing Date for Applications: | May 16, 2019 |
| Current Closing Date for Applications: | May 16, 2019 |
| Archive Date: | Jun 21, 2019 |
| Estimated Total Program Funding: | $2,000,000 |
| Award Ceiling: | $250,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Small businesses Native American tribal governments (Federally recognized) State governments Independent school districts County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Chemical modifications of protein, DNA and RNA nucleoside moieties play critical roles in regulating gene expression. Emerging evidence suggests RNA modifications have substantive roles in multiple basic biological processes. Epitranscriptomics can be defined as the aggregate suite of functional biochemical modifications to the transcriptome within a cell. Recent studies in yeast, Drosophila, rodent and human models demonstrate that stressors can induce RNA modifications, with specific reprogramming of some regulatory RNAs. The NIEHS seeks to solicit innovative, mechanistic research applications that are focused on how environmental exposures are associated and involved with the functional activities of RNA modifications and pathways that may be modified or misregulated, associated with adverse health outcomes and/or be useful as biomarkers of exposure and/or exposure-induced pathologies. The study of functional chemical RNA modification has identified important emerging roles in cellular regulation and gene expression. However, the impact of environmental exposures on functional RNA modifications has been relatively understudied and may present a new mechanism for enhanced understanding the relationships between exposures and the development of complex human diseases. The NIEHS will use the R01 mechanism to support hypothesis driven research using approaches that incorporate principles of toxicology with RNA modification biological and/or chemical expertise and utilizes state of the art technologies. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-19-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00248204 | Apr 16, 2019 | May 16, 2019 | View |
Package 1
Mandatory forms
312763 RR_SF424_2_0-2.0.pdf
312763 PHS398_CoverPageSupplement_4_0-4.0.pdf
312763 RR_OtherProjectInfo_1_4-1.4.pdf
312763 PerformanceSite_2_0-2.0.pdf
312763 RR_KeyPersonExpanded_2_0-2.0.pdf
312763 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
312763 RR_Budget_1_4-1.4.pdf
312763 RR_SubawardBudget30_1_4-1.4.pdf
312763 PHS398_ModularBudget_1_2-1.2.pdf
312763 PHS_AssignmentRequestForm_2_0-2.0.pdf
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