The National Institute of Environmental Health Sciences is offering the TaRGET II grant to establish a Data Coordination Center for the TaRGET II Consortium. This grant aims to examine the impact of environmental exposures on epigenomic marks using surrogate tissue epigenomic analysis. The Data Coordination Center will collect, store, and curate data and tools generated by consortium members to develop a public database. This initiative seeks to understand environmental influences on epigenetic mechanisms and transcriptional regulation, providing valuable insights into disease susceptibility and environmental toxicants’ effects on chromatin structure and non-coding RNAs.
Opportunity ID: 275714
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-ES-15-002 |
| Funding Opportunity Title: | TaRGET II: Environmental Epigenomics Data Coordination Center (U24) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Environment Health |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 07, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jun 24, 2015 |
| Current Closing Date for Applications: | Jun 24, 2015 |
| Archive Date: | Jul 25, 2015 |
| Estimated Total Program Funding: | $1,000,000 |
| Award Ceiling: | $600,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Small businesses City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education County governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Environmental exposure induced perturbations of epigenomic marks have been correlated with multiple aspects of disease pathogenesis.In 2012, the National Institute of Environmental Health Sciences established the multi-phased Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET) Program to further address the role of the environment in disease susceptibility as a function of changes to the epigenome.The first phase of this program, TaRGET I (RFA-ES-12-008 TaRGET I: Chromatin Structure, Genomics, and Transcriptional Responses to the Environment) solicited and funded applications pursuing research objectives aimed at understanding environmental influences on epigenetic mechanisms and transcriptional regulation. These grants consider the impact of environmental toxicants on the following processes: nucleosome positioning, chromatin accessibility, chromatin remodeling and the role of non-coding RNAs. The NIEHS has also awarded a number of unsolicited grants in the past two years with specific aims that are compatible with the stated goals of the TaRGET I FOA using a variety of model systems.However, identifying changes in epigenomic marks, (DNA methylation, histone modifications, chromatin accessibility) in tissues/cells affected by disease relevant environmental exposures as a research strategy is not always feasible in humans. The purpose of this Funding Opportunity Announcement (FOA) is to establish The TaRGET Data Coordination Center to participate in the TaRGET II Consortium (T2C) which will assess the utility of surrogate tissue epigenomic analysis as a means to examine the role of environmental exposures on epigenomic marks. The role of the TaRGET DCC will be to collect, store, curate, and display all data, metadata, and analysis tools generated by members of the T2C. This FOA is published in parallel with a companion FOA, RFA-ES-15-001 “TaRGET II: Environmental Epigenomic Analysis in Tissue Surrogates (U01)”. Projects funded by these FOAs will collectively form the TaRGET II Consortium (T2C) and will develop a publically accessible database that provides data to the broader scientific community on the conservation of environmental exposure induced epigenomic changes in target tissues and cells and selected surrogates. The T2C will be charged with establishing models that can predict and understand exposures/conditions that will be informative. These models will be developed by the research projects supported by awards from the companion RFA (RFA-ES-15-001, U01, TaRGET II: Environmental Epigenomic Analysis in Tissue Surrogates). |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-15-002.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00216038 | May 24, 2015 | Jun 24, 2015 | View |
Package 1
Mandatory forms
275714 RR_SF424_2_0-2.0.pdf
275714 PHS398_ResearchPlan_2_0-2.0.pdf
275714 PHS398_CoverPageSupplement_2_0-2.0.pdf
275714 RR_Budget_1_3-1.3.pdf
275714 RR_KeyPersonExpanded_2_0-2.0.pdf
275714 RR_OtherProjectInfo_1_3-1.3.pdf
275714 PerformanceSite_2_0-2.0.pdf
Optional forms
275714 PlannedReport-1.0.pdf
275714 PHS398_CumulativeInclusionReport-1.0.pdf
275714 RR_SubawardBudget30_1_3-1.3.pdf
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