The National Institute of General Medical Sciences (NIGMS) offers the Maximizing Investigators’ Research Award (MIRA) (R35) for Early Stage Investigators (ESI). This grant funds a research program in an ESI’s lab, including multiple projects relevant to the NIGMS mission. Its purpose is to increase the efficiency and efficacy of NIGMS funding by providing flexible support for an investigator’s overall research, rather than strict project-specific grants. This allows ESIs to adapt and pursue new discoveries. Open to proposals with or without clinical trials, the MIRA grant empowers emerging scientists to establish and expand independent research, fostering innovation in foundational biomedical science.
Opportunity ID: 347720
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-23-145 |
| Funding Opportunity Title: | Maximizing Investigators Research Award (MIRA) for Early Stage Investigators (ESI) (R35 – Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.859 — Biomedical Research and Research Training |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Apr 24, 2023 |
| Last Updated Date: | Jun 10, 2024 |
| Original Closing Date for Applications: | Feb 03, 2026 |
| Current Closing Date for Applications: | Feb 03, 2026 |
| Archive Date: | Mar 11, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $275,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education County governments Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments City or township governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
The Maximizing Investigators’ Research Award (MIRA) under this Notice of Funding Opportunity (NOFO) provides support for a program of research in an early stage investigator’s laboratory that falls within the mission of NIGMS. For the purpose of this NOFO, a program of research is a collection of projects in the investigator’s lab that are relevant to the mission of NIGMS. The goal of MIRA is to increase the efficiency and efficacy of NIGMS funding. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-23-145.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| updated award budget as per NOT-GM-24-042 | Jun 10, 2024 | |
| Apr 24, 2023 | ||
| May 22, 2023 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-23-145 |
| Funding Opportunity Title: | Maximizing Investigators Research Award (MIRA) for Early Stage Investigators (ESI) (R35 – Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.859 — Biomedical Research and Research Training |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Apr 24, 2023 |
| Last Updated Date: | Jun 10, 2024 |
| Original Closing Date for Applications: | Feb 03, 2026 |
| Current Closing Date for Applications: | Feb 03, 2026 |
| Archive Date: | Mar 11, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $275,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education County governments Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments City or township governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
The Maximizing Investigators’ Research Award (MIRA) under this Notice of Funding Opportunity (NOFO) provides support for a program of research in an early stage investigator’s laboratory that falls within the mission of NIGMS. For the purpose of this NOFO, a program of research is a collection of projects in the investigator’s lab that are relevant to the mission of NIGMS. The goal of MIRA is to increase the efficiency and efficacy of NIGMS funding. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-23-145.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-23-145 |
| Funding Opportunity Title: | Maximizing Investigators Research Award (MIRA) for Early Stage Investigators (ESI) (R35 – Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.859 — Biomedical Research and Research Training |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 24, 2023 |
| Last Updated Date: | Apr 24, 2023 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Feb 03, 2026 |
| Archive Date: | Mar 11, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $250,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses Native American tribal governments (Federally recognized) State governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Private institutions of higher education County governments City or township governments Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The Maximizing Investigators’ Research Award (MIRA) under this Notice of Funding Opportunity (NOFO) provides support for a program of research in an early stage investigator’s laboratory that falls within the mission of NIGMS. For the purpose of this NOFO, a program of research is a collection of projects in the investigator’s lab that are relevant to the mission of NIGMS. The goal of MIRA is to increase the efficiency and efficacy of NIGMS funding. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-23-145.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
DISPLAYING: Forecast 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | NOT-GM-23-017 |
| Funding Opportunity Title: | Notice of Intent to Publish a Funding Opportunity Announcement for Maximizing Investigators� Research Award (MIRA) for Early Stage Investigators (ESI) (R35 – Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.859 — Biomedical Research and Research Training |
| Cost Sharing or Matching Requirement: | No |
| Version: | Forecast 1 |
| Posted Date: | May 22, 2023 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | – |
| Archive Date: | Apr 23, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $275,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Small businesses Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) State governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts For profit organizations other than small businesses Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Notice is to inform the biomedical research community that NIGMS is planning to issue a Funding Opportunity Announcement (FOA) to continue the�Maximizing Investigators� Research Award for Early Stage Investigators (MIRA-ESI) (R35) program. The FOA is intended for new applications from�Early Stage Investigators. This Notice is being provided to allow potential applicants sufficient time to develop responsive projects.The FOA is expected to be published in Spring 2023 with an expected first application due date in October 2023. This FOA will utilize the R35 activity code. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
–
Email:- |
Related Documents
Folder 347720 Full Announcement-PAR-23-145 -> PAR-23-145-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or before January 24, 2025 | PKG00281325 | Sep 03, 2023 | Jan 24, 2025 | View | |
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289011 | Nov 25, 2024 | Feb 03, 2026 | View |
Package 1
Mandatory forms
347720 RR_SF424_5_0-5.0.pdf
347720 PHS398_CoverPageSupplement_5_0-5.0.pdf
347720 RR_OtherProjectInfo_1_4-1.4.pdf
347720 PerformanceSite_4_0-4.0.pdf
347720 RR_KeyPersonExpanded_4_0-4.0.pdf
347720 RR_Budget10_3_0-3.0.pdf
347720 PHS398_ResearchPlan_5_0-5.0.pdf
347720 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
347720 RR_SubawardBudget10_30_3_0-3.0.pdf
347720 PHS_AssignmentRequestForm_4_0-4.0.pdf
Package 2
Mandatory forms
347720 RR_SF424_5_0-5.0.pdf
347720 PHS398_CoverPageSupplement_5_0-5.0.pdf
347720 RR_OtherProjectInfo_1_4-1.4.pdf
347720 PerformanceSite_4_0-4.0.pdf
347720 RR_KeyPersonExpanded_4_0-4.0.pdf
347720 RR_Budget10_3_0-3.0.pdf
347720 PHS398_ResearchPlan_5_0-5.0.pdf
347720 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
347720 RR_SubawardBudget10_30_3_0-3.0.pdf
347720 PHS_AssignmentRequestForm_3_0-3.0.pdf
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