The National Institutes of Health is offering a grant to support research in developing biomarkers for small vessel cerebrovascular disease in human vascular contributions to cognitive impairment and dementia. The funded projects will evaluate predictive, diagnostic, and progression biomarkers for VCID and vascular/Alzheimer’s mixed dementias. The grant aims to establish a consortium for collaborative research and further develop promising biomarker candidates for FDA qualification and clinical validation studies. The closing date for applications is May 10, 2016.
Opportunity ID: 281840
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-16-020 |
| Funding Opportunity Title: | Small Vessel Vascular Contributions to Cognitive Impairment and Dementia (VCID) Biomarkers Development Projects (UH2/UH3) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 26, 2016 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | May 10, 2016 |
| Current Closing Date for Applications: | May 10, 2016 |
| Archive Date: | Jun 10, 2016 |
| Estimated Total Program Funding: | $5,000,000 |
| Award Ceiling: | $750,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Private institutions of higher education Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this funding opportunity announcement (FOA) is to support research that evaluates and further develops candidate predictive, diagnostic, target engagement and progression candidate biomarkers of small vessel cerebrovascular disease in human vascular contributions to cognitive impairment and dementia (VCID) and vascular/Alzheimer’s mixed dementias. Biomarkers development projects funded under this FOA, with support from the Coordinating Center (RFA-NS-16-019), will: study biomarkers as individual projects and concurrently establish the interactive consortium (UH2, years 1-2); and then work together as a consortium to perform collaborative cross-project multi-disciplinary studies to further evaluate and develop the most promising biomarker candidates (UH3, years 3-5) to the point of being ready for large scale multi-site clinical validation studies including towards FDA qualification of small vessel VCID biomarkers for phase II and phase III clinical trials (to be carried out under future separate funding). |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-16-020.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00221203 | Apr 10, 2016 | May 10, 2016 | View |
Package 1
Mandatory forms
281840 RR_SF424_2_0-2.0.pdf
281840 PHS398_ResearchPlan_2_0-2.0.pdf
281840 PHS398_CoverPageSupplement_2_0-2.0.pdf
281840 RR_Budget_1_3-1.3.pdf
281840 RR_KeyPersonExpanded_2_0-2.0.pdf
281840 RR_OtherProjectInfo_1_3-1.3.pdf
281840 PerformanceSite_2_0-2.0.pdf
Optional forms
281840 PlannedReport-1.0.pdf
281840 PHS398_CumulativeInclusionReport-1.0.pdf
281840 RR_SubawardBudget30_1_3-1.3.pdf
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