The National Institutes of Health (NIH) is offering the CounterACT Translational Exploratory/Developmental Research Project grant. This grant supports research aimed at discovering and developing novel medical countermeasures (MCMs) to address severe morbidity and mortality following acute exposure to highly toxic chemical threats. These threats encompass chemical warfare agents, industrial chemicals, pesticides, and ultra-potent synthetic opioids. The initiative focuses on translational research, including preliminary efficacy and early preclinical development studies for new molecular entities, biologics, or repurposed FDA-approved products. The purpose of this funding is to generate essential preliminary data, enabling competitive applications for more extensive support through the NIH CounterACT Cooperative Agreement program and related initiatives.
Opportunity ID: 356848
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-114 |
| Funding Opportunity Title: | CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Translational Exploratory/Developmental Research Projects (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Environment Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 25, 2024 |
| Last Updated Date: | Oct 25, 2024 |
| Original Closing Date for Applications: | May 30, 2025 |
| Current Closing Date for Applications: | May 30, 2025 |
| Archive Date: | Jul 05, 2025 |
| Estimated Total Program Funding: | $275,000 |
| Award Ceiling: | $275,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses Public and State controlled institutions of higher education State governments For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Native American tribal governments (Federally recognized) Special district governments Private institutions of higher education Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Notice of Funding Opportunity (NOFO) supports translational exploratory/developmental research that directly advances the discovery of novel treatment strategies, i.e., medical countermeasures (MCMs), that address serious morbidity and mortality after acute exposure to highly toxic chemical threats. Chemical threats are toxic compounds that could be used in a terrorist attack or accidentally released from industrial production, storage, or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, pesticides, and ultra-potent synthetic (UPS) opioids. This NOFO supports translational research that includes, but is not limited to, preliminary efficacy and/or early preclinical development studies towards discovery and validation of novel molecular entities or biologics as candidate MCMs. In addition to novel agents, new treatment strategies may involve repurposing already FDA-approved products or combinations of interventions based on established mechanisms of action. Projects supported by this NOFO are expected to generate preliminary data that would facilitate the development of competitive applications for more extensive support from the NIH CounterACT Cooperative Agreement program and/or other related initiatives. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-114.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356848 Full Announcement-PAR-25-114 -> PAR-25-114-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288425 | Apr 30, 2025 | May 30, 2025 | View |
Package 1
Mandatory forms
356848 RR_SF424_5_0-5.0.pdf
356848 PHS398_CoverPageSupplement_5_0-5.0.pdf
356848 RR_OtherProjectInfo_1_4-1.4.pdf
356848 PerformanceSite_4_0-4.0.pdf
356848 RR_KeyPersonExpanded_4_0-4.0.pdf
356848 PHS398_ResearchPlan_5_0-5.0.pdf
356848 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356848 RR_Budget_3_0-3.0.pdf
356848 RR_SubawardBudget30_3_0-3.0.pdf
356848 PHS398_ModularBudget_1_2-1.2.pdf
356848 PHS_AssignmentRequestForm_4_0-4.0.pdf
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