This NIH grant aims to support the phenotyping and research of knockout mouse strains with embryonic or perinatal lethality, created through the International Mouse Phenotyping Consortium (IMPC). With the potential to work on 2,500 existing strains and an additional 6,000 planned, researchers can delve into the 30% of strains expected to show lethal or subviable characteristics. Leveraging the generation of 20,000 KO strains, scientists have a unique window to conduct in-depth studies while these strains are still in production.
Opportunity ID: 289386
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-17-005 |
| Funding Opportunity Title: | In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 07, 2016 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 05, 2019 |
| Current Closing Date for Applications: | Nov 05, 2019 |
| Archive Date: | Dec 06, 2019 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $499,999 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Small businesses State governments Private institutions of higher education County governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to phenotype and/or perform research on embryonic lethal knockout (KO) mouse strains being generated through the International Mouse Phenotyping Consortium (IMPC) of which the NIH Knockout Mouse Phenotyping Program (KOMP2) is a member. The KOMP2 KO mouse phenotyping effort has generated 2,500 mouse strains with plans to generate an additional 6,000 over the next five years. Overall, the IMPC hopes to achieve broad-based phenotyping of 20,000 KO strains. About 30% of these strains either are or are expected to be embryonic or perinatal lethal or subviable. A large portion of homozygous lethal mutations are expected to have viable heterozygous phenotypes. The scientific community has the unique opportunity to leverage these mouse strains while they are being created and bred as part of the IMPC adult mouse phenotyping effort to perform additional in depth phenotyping and research. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-17-005.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-D | Use for due dates on or before January 24, 2018 | PKG00228486 | May 05, 2017 | Jan 24, 2018 | View | |
| FORMS-E | Use for due dates on or after January 25, 2018 | PKG00235825 | Nov 07, 2017 | Nov 05, 2019 | View |
Package 1
Mandatory forms
289386 RR_SF424_2_0-2.0.pdf
289386 PHS398_CoverPageSupplement_3_0-3.0.pdf
289386 RR_OtherProjectInfo_1_3-1.3.pdf
289386 PerformanceSite_2_0-2.0.pdf
289386 RR_KeyPersonExpanded_2_0-2.0.pdf
289386 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
289386 RR_Budget_1_3-1.3.pdf
289386 RR_SubawardBudget30_1_3-1.3.pdf
289386 PHS398_ModularBudget_1_2-1.2.pdf
289386 PHS_Inclusion_Enrollment_Report-1.0.pdf
289386 PHS_AssignmentRequestForm-1.0.pdf
Package 2
Mandatory forms
289386 RR_SF424_2_0-2.0.pdf
289386 PHS398_CoverPageSupplement_4_0-4.0.pdf
289386 RR_OtherProjectInfo_1_4-1.4.pdf
289386 PerformanceSite_2_0-2.0.pdf
289386 RR_KeyPersonExpanded_2_0-2.0.pdf
289386 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
289386 RR_Budget_1_4-1.4.pdf
289386 RR_SubawardBudget30_1_4-1.4.pdf
289386 PHS398_ModularBudget_1_2-1.2.pdf
289386 PHS_AssignmentRequestForm_2_0-2.0.pdf
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