This NIH grant aims to support small businesses in developing innovative approaches incorporating genetic diversity into toxicity testing. The goal is to create screening systems that can better reflect the variability in human populations’ responses to chemical exposure. Current toxicology testing often lacks diversity, leading to potentially missed clinically relevant toxic effects. Proposals for Phase I, Direct to Phase II, and Fast Track SBIR grants are welcome to develop resources such as cell panels or model organisms. The deadline for submissions is February 19, 2020, 12:00 AM EST.
Opportunity ID: 322775
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-ES-20-008 |
| Funding Opportunity Title: | New Approaches for Incorporating Genetic Diversity into Toxicity Testing (R43/R44 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Environment Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 27, 2019 |
| Last Updated Date: | Nov 27, 2019 |
| Original Closing Date for Applications: | Feb 19, 2020 |
| Current Closing Date for Applications: | Feb 19, 2020 |
| Archive Date: | Mar 26, 2020 |
| Estimated Total Program Funding: | $3,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) supports Phase I (R43), Direct to Phase II (R44), and Fast Track (R44) Small Business Innovative Research (SBIR) grant proposals from small businesses concerns (SBCs) to develop resources and approaches, including panels of cells or model organisms, that can better reflect the variability in human populations in chemical toxicity testing. Current toxicology testing is often limited to studies conducted in a small number of laboratory rodent strains, which can fail to identify clinically relevant toxicity if the conventional rodent strain is particularly resistant to the toxic effects of the test compound. Cost-effective screening systems with appropriate throughput are needed to capture the variability in responses to chemical exposure in the human population based on genetic diversity. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-20-008.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00256886 | Jan 19, 2020 | Feb 19, 2020 | View |
Package 1
Mandatory forms
322775 RR_SF424_2_0-2.0.pdf
322775 PHS398_CoverPageSupplement_4_0-4.0.pdf
322775 RR_OtherProjectInfo_1_4-1.4.pdf
322775 PerformanceSite_2_0-2.0.pdf
322775 RR_KeyPersonExpanded_2_0-2.0.pdf
322775 RR_Budget_1_4-1.4.pdf
322775 PHS398_ResearchPlan_4_0-4.0.pdf
322775 SBIR_STTR_Information_1_2-1.2.pdf
Optional forms
322775 RR_SubawardBudget30_1_4-1.4.pdf
322775 PHS_AssignmentRequestForm_2_0-2.0.pdf
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