This department is offering a grant to establish a Tissue Chip Testing Center (TCTC) to validate tissue chips developed under the NIH Tissue Chip (TC) Program or NIH Microphysiological Systems (MPS) Program. The TCTC will conduct testing of pharmaceutical compounds using specific assays to assess biomarkers, bioavailability, efficacy, and toxicity prior to clinical trials. The aim is to create accurate cellular and organ microsystems that replicate human physiology for better drug evaluation. Applicants must submit proposals by May 17, 2016.
Opportunity ID: 282308
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-TR-16-006 |
| Funding Opportunity Title: | Tissue Chip Testing Centers: Validating Microphysiological Systems (U24) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.350 — National Center for Advancing Translational Sciences |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 17, 2016 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | May 17, 2016 |
| Current Closing Date for Applications: | May 17, 2016 |
| Archive Date: | Jun 17, 2016 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $1,000,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments Special district governments Private institutions of higher education Independent school districts Public and State controlled institutions of higher education Small businesses Public housing authorities/Indian housing authorities City or township governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) invites applications for Tissue Chip Testing Center(s) (TCTC) that will provide resources and infrastructure for the validation of tissue chips being developed as part of the NIH Tissue Chip (TC) Program or NIH Microphysiological Systems (MPS) Program. The MPS program supports a consortium of investigators developing accurate cellular and organ microsystems representative of human physiology for the evaluation of drug efficacy and toxicity (RFA-RM-11-022).The developed in vitro MPS platforms are representative of major organs and tissues in the human body and need to be validated for their predictive capabilities in the assessment of biomarkers, and the bioavailability, efficacy, and toxicity of therapeutic agents prior to entry into clinical trials.Validation of the tissue chips will be conducted through the TCTC that will be responsible for the testing of a select group of compounds using predefined assays and biomarkers according to pharmaceutical industry standards, and for the integration of the data into a public database. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-16-006.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00221706 | Apr 17, 2016 | May 17, 2016 | View |
Package 1
Mandatory forms
282308 RR_SF424_2_0-2.0.pdf
282308 PHS398_ResearchPlan_2_0-2.0.pdf
282308 PHS398_CoverPageSupplement_2_0-2.0.pdf
282308 RR_Budget_1_3-1.3.pdf
282308 RR_KeyPersonExpanded_2_0-2.0.pdf
282308 RR_OtherProjectInfo_1_3-1.3.pdf
282308 PerformanceSite_2_0-2.0.pdf
Optional forms
282308 PlannedReport-1.0.pdf
282308 PHS398_CumulativeInclusionReport-1.0.pdf
282308 RR_SubawardBudget30_1_3-1.3.pdf
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