This grant from the National Institutes of Health supports multi-disciplinary teams in investigating somatic genomic perturbations in human brain samples to understand their role in neuropsychiatric disorders. The grant aims to uncover the full spectrum of somatic variations across different brain regions using cutting-edge genomics and computational techniques. A Brain Somatic Mosaicism Network Steering Committee oversees research coordination and data analysis. The goal is to enhance our comprehension of somatic genomic influences on neuropsychiatric disorder development. Multiple collaborating sites are necessary, each requiring identical research strategies, with unique function descriptions. Applications must ensure cross-site coordination and data sharing for successful completion of the research.
Opportunity ID: 268986
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-15-022 |
| Funding Opportunity Title: | Brain Somatic Mosaicism and its Role in Psychiatric Disorders (Collaborative U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 3 |
| Posted Date: | Oct 22, 2014 |
| Last Updated Date: | Aug 21, 2015 |
| Original Closing Date for Applications: | Feb 24, 2017 |
| Current Closing Date for Applications: | Aug 21, 2015 |
| Archive Date: | Sep 21, 2015 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Independent school districts Public housing authorities/Indian housing authorities State governments Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement (FOA) invites Cooperative Agreement (U01) applications from multi-disciplinary and synergistic teams of investigators proposing to identify and characterize the full spectrum of somatic variation in human brain samples and to assess the relationship of such variation with the pathophysiology of neuropsychiatric disorders. This FOA seeks to support applications exploring the extent of somatic variations across different brain regions in one or more psychiatric disorders using state-of-the-art genomic, computational, single-cell and other relevant approaches. Awards made under this FOA and the companion FOA (PAR-14-173) will be governed by a Brain Somatic Mosaicism (BSM) Network Steering Committee to accelerate scientific progress through the coordination of research strategies, analytical methods and data. The ultimate goal of this FOA and the companion FOA (PAR-14-173) is to address gaps in our understanding of the role of somatic genomic perturbations in the etiology of neuropsychiatric disorders. This FOA should be used when two or more collaborating sites are essential to complete the proposed research. It is required that the Research Strategy be identical across linked collaborative U01 applications, with the exception of a short section describing specific function of each application under “elements unique to that site.” For a linked set of collaborative U01 applications, each application must have its own Program Directory/Principal Investigator (PD/PI) and the program must provide a mechanism for cross-site coordination, quality control, data and sample sharing among the BSM Network members as appropriate, database management, statistical analysis, and reporting. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-15-022.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Modified the archiving date. | Aug 21, 2015 | |
| Modified close date field, in accordance with NOT-MH-15-026. | Aug 21, 2015 | |
| Aug 21, 2015 |
DISPLAYING: Synopsis 3
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-15-022 |
| Funding Opportunity Title: | Brain Somatic Mosaicism and its Role in Psychiatric Disorders (Collaborative U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 3 |
| Posted Date: | Oct 22, 2014 |
| Last Updated Date: | Aug 21, 2015 |
| Original Closing Date for Applications: | Feb 24, 2017 |
| Current Closing Date for Applications: | Aug 21, 2015 |
| Archive Date: | Sep 21, 2015 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Independent school districts Public housing authorities/Indian housing authorities State governments Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement (FOA) invites Cooperative Agreement (U01) applications from multi-disciplinary and synergistic teams of investigators proposing to identify and characterize the full spectrum of somatic variation in human brain samples and to assess the relationship of such variation with the pathophysiology of neuropsychiatric disorders. This FOA seeks to support applications exploring the extent of somatic variations across different brain regions in one or more psychiatric disorders using state-of-the-art genomic, computational, single-cell and other relevant approaches. Awards made under this FOA and the companion FOA (PAR-14-173) will be governed by a Brain Somatic Mosaicism (BSM) Network Steering Committee to accelerate scientific progress through the coordination of research strategies, analytical methods and data. The ultimate goal of this FOA and the companion FOA (PAR-14-173) is to address gaps in our understanding of the role of somatic genomic perturbations in the etiology of neuropsychiatric disorders. This FOA should be used when two or more collaborating sites are essential to complete the proposed research. It is required that the Research Strategy be identical across linked collaborative U01 applications, with the exception of a short section describing specific function of each application under “elements unique to that site.” For a linked set of collaborative U01 applications, each application must have its own Program Directory/Principal Investigator (PD/PI) and the program must provide a mechanism for cross-site coordination, quality control, data and sample sharing among the BSM Network members as appropriate, database management, statistical analysis, and reporting. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-15-022.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-15-022 |
| Funding Opportunity Title: | Brain Somatic Mosaicism and its Role in Psychiatric Disorders (Collaborative U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Aug 21, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Aug 21, 2015 |
| Archive Date: | Mar 27, 2017 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Special district governments Independent school districts Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments County governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement (FOA) invites Cooperative Agreement (U01) applications from multi-disciplinary and synergistic teams of investigators proposing to identify and characterize the full spectrum of somatic variation in human brain samples and to assess the relationship of such variation with the pathophysiology of neuropsychiatric disorders. This FOA seeks to support applications exploring the extent of somatic variations across different brain regions in one or more psychiatric disorders using state-of-the-art genomic, computational, single-cell and other relevant approaches. Awards made under this FOA and the companion FOA (PAR-14-173) will be governed by a Brain Somatic Mosaicism (BSM) Network Steering Committee to accelerate scientific progress through the coordination of research strategies, analytical methods and data. The ultimate goal of this FOA and the companion FOA (PAR-14-173) is to address gaps in our understanding of the role of somatic genomic perturbations in the etiology of neuropsychiatric disorders. This FOA should be used when two or more collaborating sites are essential to complete the proposed research. It is required that the Research Strategy be identical across linked collaborative U01 applications, with the exception of a short section describing specific function of each application under “elements unique to that site.” For a linked set of collaborative U01 applications, each application must have its own Program Directory/Principal Investigator (PD/PI) and the program must provide a mechanism for cross-site coordination, quality control, data and sample sharing among the BSM Network members as appropriate, database management, statistical analysis, and reporting. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-15-022.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-15-022 |
| Funding Opportunity Title: | Brain Somatic Mosaicism and its Role in Psychiatric Disorders (Collaborative U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 21, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Feb 24, 2017 |
| Archive Date: | Mar 27, 2017 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Special district governments Independent school districts Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments County governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement (FOA) invites Cooperative Agreement (U01) applications from multi-disciplinary and synergistic teams of investigators proposing to identify and characterize the full spectrum of somatic variation in human brain samples and to assess the relationship of such variation with the pathophysiology of neuropsychiatric disorders. This FOA seeks to support applications exploring the extent of somatic variations across different brain regions in one or more psychiatric disorders using state-of-the-art genomic, computational, single-cell and other relevant approaches. Awards made under this FOA and the companion FOA (PAR-14-173) will be governed by a Brain Somatic Mosaicism (BSM) Network Steering Committee to accelerate scientific progress through the coordination of research strategies, analytical methods and data. The ultimate goal of this FOA and the companion FOA (PAR-14-173) is to address gaps in our understanding of the role of somatic genomic perturbations in the etiology of neuropsychiatric disorders.
This FOA should be used when two or more collaborating sites are essential to complete the proposed research. It is required that the Research Strategy be identical across linked collaborative U01 applications, with the exception of a short section describing specific function of each application under “elements unique to that site.” For a linked set of collaborative U01 applications, each application must have its own Program Directory/Principal Investigator (PD/PI) and the program must provide a mechanism for cross-site coordination, quality control, data and sample sharing among the BSM Network members as appropriate, database management, statistical analysis, and reporting. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-15-022.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.242 | FORMS-C | FORMS-C | PKG00209237 | Jan 24, 2015 | Aug 22, 2015 | View |
Package 1
Mandatory forms
268986 RR_SF424_2_0-2.0.pdf
268986 PHS398_ResearchPlan_2_0-2.0.pdf
268986 PHS398_CoverPageSupplement_2_0-2.0.pdf
268986 RR_KeyPersonExpanded_2_0-2.0.pdf
268986 RR_OtherProjectInfo_1_3-1.3.pdf
268986 PerformanceSite_2_0-2.0.pdf
Optional forms
268986 RR_SubawardBudget30_1_3-1.3.pdf
268986 PlannedReport-1.0.pdf
268986 PHS398_CumulativeInclusionReport-1.0.pdf
268986 PHS398_ModularBudget_1_2-1.2.pdf
268986 RR_Budget_1_3-1.3.pdf
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