This NIH grant is for supporting innovative research aimed at illuminating the fundamental mechanisms that lead to the formation of structural birth defects. It specifically encourages projects that integrate animal models with robust human translational and clinical approaches. Applicants should utilize cutting-edge advances in genetics, various omics methodologies (including genomics, proteomics, and metabolomics), synthetic biology, and biochemical developmental biology. The primary objective is to identify precise genetic, epigenetic, environmental, or complex gene-environment interactions associated with the formation, individual susceptibility, and variability observed in structural birth defects within human populations. This funding aims to significantly deepen our understanding of these critical congenital malformations.
Opportunity ID: 357008
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-146 |
| Funding Opportunity Title: | Advancing Research to Understand Congenital Malformations (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.865 — Child Health and Human Development Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 06, 2024 |
| Last Updated Date: | Nov 06, 2024 |
| Original Closing Date for Applications: | Sep 07, 2025 |
| Current Closing Date for Applications: | Sep 07, 2025 |
| Archive Date: | Oct 13, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education City or township governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Public housing authorities/Indian housing authorities Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this notices of funding opportunity (NOFO) is to support innovative research that will inform our understanding of the mechanisms underlying the formation of structural birth defects using animal models in conjunction with human translational/clinical approaches. Applicants are encouraged to take advantage of advances in genetics, omics methods (genomics, proteomics, metabolomics, etc.), and synthetic biology, biochemical and other approaches to developmental biology research to identify specific genetic, epigenetic, environmental, or gene/environment interactions associated with the formation of, susceptibility to, and variability of structural birth defects in human populations. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-146.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357008 Full Announcement-PAR-25-146 -> PAR-25-146-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288547 | Jan 05, 2025 | Sep 07, 2025 | View |
Package 1
Mandatory forms
357008 RR_SF424_5_0-5.0.pdf
357008 PHS398_CoverPageSupplement_5_0-5.0.pdf
357008 RR_OtherProjectInfo_1_4-1.4.pdf
357008 PerformanceSite_4_0-4.0.pdf
357008 RR_KeyPersonExpanded_4_0-4.0.pdf
357008 PHS398_ResearchPlan_5_0-5.0.pdf
357008 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357008 RR_Budget_3_0-3.0.pdf
357008 RR_SubawardBudget30_3_0-3.0.pdf
357008 PHS398_ModularBudget_1_2-1.2.pdf
357008 PHS_AssignmentRequestForm_4_0-4.0.pdf
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