This grant, offered by the National Institutes of Health (NIH), supports innovative research aimed at elucidating the mechanisms underlying structural birth defect formation. The program encourages the use of animal models integrated with human translational/clinical approaches. Applicants should leverage advances in genetics, various omics methods (genomics, proteomics, metabolomics), synthetic biology, and biochemical approaches within developmental biology. The primary goal is to identify specific genetic, epigenetic, environmental factors, or gene-environment interactions. This research seeks to understand the formation, susceptibility, and variability of structural birth defects in human populations, advancing our fundamental knowledge in this critical area.
Opportunity ID: 343054
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-215 |
| Funding Opportunity Title: | Advancing Research to Understand Congenital Malformations (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.865 — Child Health and Human Development Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Aug 09, 2022 |
| Last Updated Date: | Nov 06, 2024 |
| Original Closing Date for Applications: | Sep 07, 2025 |
| Current Closing Date for Applications: | Nov 05, 2024 |
| Archive Date: | Dec 05, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $499,999 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses Public and State controlled institutions of higher education Special district governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments Independent school districts Private institutions of higher education City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
The purpose of this funding opportunity announcement (FOA) is to support innovative research that will inform our understanding of the mechanisms underlying the formation of structural birth defects using animal models in conjunction with human translational/clinical approaches. Applicants are encouraged to take advantage of advances in genetics, omics methods (genomics, proteomics, metabolomics, etc.), and synthetic biology, biochemical and other approaches to developmental biology research to identify specific genetic, epigenetic, environmental, or gene/environment interactions associated with the formation of, susceptibility to, and variability of structural birth defects in human populations. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-22-215.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Update close date per reissued NOFO PAR-25-146. | Nov 06, 2024 | |
| Aug 09, 2022 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-215 |
| Funding Opportunity Title: | Advancing Research to Understand Congenital Malformations (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.865 — Child Health and Human Development Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Aug 09, 2022 |
| Last Updated Date: | Nov 06, 2024 |
| Original Closing Date for Applications: | Sep 07, 2025 |
| Current Closing Date for Applications: | Nov 05, 2024 |
| Archive Date: | Dec 05, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $499,999 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses Public and State controlled institutions of higher education Special district governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments Independent school districts Private institutions of higher education City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
The purpose of this funding opportunity announcement (FOA) is to support innovative research that will inform our understanding of the mechanisms underlying the formation of structural birth defects using animal models in conjunction with human translational/clinical approaches. Applicants are encouraged to take advantage of advances in genetics, omics methods (genomics, proteomics, metabolomics, etc.), and synthetic biology, biochemical and other approaches to developmental biology research to identify specific genetic, epigenetic, environmental, or gene/environment interactions associated with the formation of, susceptibility to, and variability of structural birth defects in human populations. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-22-215.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-215 |
| Funding Opportunity Title: | Advancing Research to Understand Congenital Malformations (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.865 — Child Health and Human Development Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 09, 2022 |
| Last Updated Date: | Aug 09, 2022 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Sep 07, 2025 |
| Archive Date: | Oct 13, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $499,999 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Native American tribal governments (Federally recognized) County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education State governments Public and State controlled institutions of higher education City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this funding opportunity announcement (FOA) is to support innovative research that will inform our understanding of the mechanisms underlying the formation of structural birth defects using animal models in conjunction with human translational/clinical approaches. Applicants are encouraged to take advantage of advances in genetics, omics methods (genomics, proteomics, metabolomics, etc.), and synthetic biology, biochemical and other approaches to developmental biology research to identify specific genetic, epigenetic, environmental, or gene/environment interactions associated with the formation of, susceptibility to, and variability of structural birth defects in human populations. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-22-215.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Related Documents
Folder 343054 Full Announcement-PAR-22-215 -> PAR-22-215-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00276371 | Sep 05, 2022 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00277820 | Nov 01, 2022 | Dec 11, 2024 | View |
Package 1
Mandatory forms
343054 RR_SF424_5_0-5.0.pdf
343054 PHS398_CoverPageSupplement_5_0-5.0.pdf
343054 RR_OtherProjectInfo_1_4-1.4.pdf
343054 PerformanceSite_4_0-4.0.pdf
343054 RR_KeyPersonExpanded_4_0-4.0.pdf
343054 PHS398_ResearchPlan_4_0-4.0.pdf
343054 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343054 RR_Budget_3_0-3.0.pdf
343054 RR_SubawardBudget30_3_0-3.0.pdf
343054 PHS398_ModularBudget_1_2-1.2.pdf
343054 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
343054 RR_SF424_5_0-5.0.pdf
343054 PHS398_CoverPageSupplement_5_0-5.0.pdf
343054 RR_OtherProjectInfo_1_4-1.4.pdf
343054 PerformanceSite_4_0-4.0.pdf
343054 RR_KeyPersonExpanded_4_0-4.0.pdf
343054 PHS398_ResearchPlan_5_0-5.0.pdf
343054 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343054 RR_Budget_3_0-3.0.pdf
343054 RR_SubawardBudget30_3_0-3.0.pdf
343054 PHS398_ModularBudget_1_2-1.2.pdf
343054 PHS_AssignmentRequestForm_3_0-3.0.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
