This NIH grant is for supporting research applications focused on the development and evaluation of novel radioligands for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging, specifically for use in the human brain. The primary purpose is to generate the necessary data to advance promising PET and SPECT ligands from preclinical studies into clinical research. This involves proposing new ligand development and conducting pilot or clinical feasibility evaluations, potentially utilizing previously collected preclinical data. The ultimate goal is to apply these advanced imaging ligands as crucial biomarkers for drug discovery initiatives and for conducting detailed pathophysiological studies related to central nervous system (CNS) disorders.
Opportunity ID: 357006
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-036 |
| Funding Opportunity Title: | Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 06, 2024 |
| Last Updated Date: | Nov 06, 2024 |
| Original Closing Date for Applications: | May 07, 2026 |
| Current Closing Date for Applications: | May 07, 2026 |
| Archive Date: | Jun 12, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) For profit organizations other than small businesses Public and State controlled institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments State governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Notice of Funding Opportunity (NOFO) invites research grant applications that propose the development and evaluation of novel radioligands for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging in human brain and the incorporation of, pilot or clinical feasibility evaluation from previously collected data in pre-clinical studies. These studies are expected to provide the requisite data needed to advance promising PET ligands for use in clinical research. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-036.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357006 Full Announcement-PAR-25-036 -> PAR-25-036-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288545 | Jan 05, 2025 | May 07, 2026 | View |
Package 1
Mandatory forms
357006 RR_SF424_5_0-5.0.pdf
357006 PHS398_CoverPageSupplement_5_0-5.0.pdf
357006 RR_OtherProjectInfo_1_4-1.4.pdf
357006 PerformanceSite_4_0-4.0.pdf
357006 RR_KeyPersonExpanded_4_0-4.0.pdf
357006 PHS398_ResearchPlan_5_0-5.0.pdf
357006 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357006 RR_Budget_3_0-3.0.pdf
357006 RR_SubawardBudget30_3_0-3.0.pdf
357006 PHS398_ModularBudget_1_2-1.2.pdf
357006 PHS_AssignmentRequestForm_4_0-4.0.pdf
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