This National Institutes of Health (NIH) grant is for the development of novel theories and methods aimed at deciphering the genetic architecture of complex human traits. It seeks applications that will enhance our understanding of how both genetic and non-genetic factors contribute to trait variation across individuals, families, and diverse populations. Proposed approaches should be interdisciplinary, drawing insights from both natural and social sciences, and must consider interdependencies across biological, social, and ecological organizational scales. Successful proposals will integrate robust theoretical frameworks, advanced modeling techniques, and rigorous validation using existing large-scale datasets. The goal is to foster innovative research that deepens our comprehension of complex trait etiology.
Opportunity ID: 357135
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-255 |
| Funding Opportunity Title: | Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 15, 2024 |
| Last Updated Date: | Nov 15, 2024 |
| Original Closing Date for Applications: | Nov 05, 2026 |
| Current Closing Date for Applications: | Nov 05, 2026 |
| Archive Date: | Dec 11, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) City or township governments For profit organizations other than small businesses Public and State controlled institutions of higher education Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this NOFO is to support applications for novel theory and methods development that enable better understanding of how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary drawing from the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, modeling, and validation with available large-scale datasets. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-255.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357135 Full Announcement-PAR-25-255 -> PAR-25-255-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288730 | Jan 05, 2025 | Nov 05, 2026 | View |
Package 1
Mandatory forms
357135 RR_SF424_5_0-5.0.pdf
357135 PHS398_CoverPageSupplement_5_0-5.0.pdf
357135 RR_OtherProjectInfo_1_4-1.4.pdf
357135 PerformanceSite_4_0-4.0.pdf
357135 RR_KeyPersonExpanded_4_0-4.0.pdf
357135 PHS398_ResearchPlan_5_0-5.0.pdf
357135 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357135 RR_Budget_3_0-3.0.pdf
357135 RR_SubawardBudget30_3_0-3.0.pdf
357135 PHS398_ModularBudget_1_2-1.2.pdf
357135 PHS_AssignmentRequestForm_4_0-4.0.pdf
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