The National Institutes of Health (NIH) is offering this grant to support critical research into the molecular mechanisms of combination adjuvants. This initiative aims to understand how two or more vaccine adjuvants function synergistically when combined. This grant is specifically for studies focused on adjuvants that have already demonstrated immune modulating activity individually. The core purpose is to advance scientific knowledge by elucidating the precise ways these combinations elicit specific immune responses. The ultimate, long-term goal of this research program is to significantly improve the rational design of future vaccines, enabling researchers to predict and tailor the immune profile generated by specific combination adjuvants, leading to more effective and targeted immunizations.
Opportunity ID: 358158
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-25-006 |
| Funding Opportunity Title: | Molecular Mechanisms of Combination Adjuvants (MMCA) (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 13, 2025 |
| Last Updated Date: | Jan 13, 2025 |
| Original Closing Date for Applications: | Jun 10, 2025 |
| Current Closing Date for Applications: | Jun 10, 2025 |
| Archive Date: | Jul 16, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses County governments City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this notice of funding opportunity (NOFO) is to support research studies of two or more vaccine adjuvants (combination adjuvants) in order to understand the mechanisms by which they work in concert. All adjuvants considered must have previously demonstrated immune modulating activity. The long-term goal of this research program is to improve the rational design of vaccines by predicting the immune profile elicited by combination adjuvants. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-25-006.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 358158 Full Announcement-RFA-AI-25-006 -> RFA-AI-25-006-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00290032 | May 10, 2025 | Jun 10, 2025 | View |
Package 1
Mandatory forms
358158 RR_SF424_5_0-5.0.pdf
358158 PHS398_CoverPageSupplement_5_0-5.0.pdf
358158 RR_OtherProjectInfo_1_4-1.4.pdf
358158 PerformanceSite_4_0-4.0.pdf
358158 RR_KeyPersonExpanded_4_0-4.0.pdf
358158 PHS398_ResearchPlan_5_0-5.0.pdf
358158 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
358158 RR_Budget_3_0-3.0.pdf
358158 RR_SubawardBudget30_3_0-3.0.pdf
358158 PHS398_ModularBudget_1_2-1.2.pdf
358158 PHS_AssignmentRequestForm_4_0-4.0.pdf
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