The National Institutes of Health (NIH) is offering this grant to advance the development of crucial animal models for Hepatitis B (HBV) and Hepatitis C (HCV) research. This grant is specifically designed to encourage investigations focused on creating convenient small animal models capable of supporting the infection and replication of either HBV or HCV. The ultimate goal for these models is to clearly demonstrate dichotomous outcomes, such as viral clearance versus persistence. Additionally, the funding supports the exploration of alternative approaches, including the development of closely related surrogate virus-host systems. Robust xenotransplantation models, dually engrafted with human liver cells and human immune systems, are also viable avenues for development under this opportunity. This initiative aims to provide essential tools for understanding and combating hepatitis.
Opportunity ID: 347176
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-23-022 |
| Funding Opportunity Title: | Animal Models for Hepatitis B and C (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 28, 2023 |
| Last Updated Date: | Mar 28, 2023 |
| Original Closing Date for Applications: | Aug 25, 2023 |
| Current Closing Date for Applications: | Aug 25, 2023 |
| Archive Date: | Sep 30, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses Special district governments Independent school districts Public housing authorities/Indian housing authorities City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) For profit organizations other than small businesses State governments County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) encourages research focused on the development of convenient small animal models that will support infection and replication of HBV and/or HCV, ideally leading to the dichotomous outcomes of clearance and persistence. Alternatively, closely related surrogate virus-host systems or robust xenotransplantation models dually engrafted with human liver cells and human immune systems can be developed. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-23-022.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 347176 Full Announcement-RFA-AI-23-022 -> RFA-AI-23-022-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00280859 | Jul 25, 2023 | Aug 25, 2023 | View |
Package 1
Mandatory forms
347176 RR_SF424_5_0-5.0.pdf
347176 PHS398_CoverPageSupplement_5_0-5.0.pdf
347176 RR_OtherProjectInfo_1_4-1.4.pdf
347176 PerformanceSite_4_0-4.0.pdf
347176 RR_KeyPersonExpanded_4_0-4.0.pdf
347176 PHS398_ResearchPlan_5_0-5.0.pdf
347176 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
347176 RR_Budget_3_0-3.0.pdf
347176 RR_SubawardBudget30_3_0-3.0.pdf
347176 PHS398_ModularBudget_1_2-1.2.pdf
347176 PHS_AssignmentRequestForm_3_0-3.0.pdf
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