This NIH grant, supported by NIMH, NIA, NICHD, and NIDCD, aims to support investigators in discovering cell-based chemical probes for novel brain targets. Its purpose is to stimulate research focused on developing novel small molecules to understand biological processes relevant to these institutes’ missions. It also seeks to discover and validate new biological targets that inform brain disease mechanisms. Applicants should possess validated starting compounds and bioassays. Projects emphasizing new insights into disease-related biological targets and processes are prioritized, with a core focus on cell-based chemical probe development.
Opportunity ID: 329437
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-21-028 |
| Funding Opportunity Title: | Discovery of Cell-based Chemical Probes for Novel Brain Targets (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 15, 2020 |
| Last Updated Date: | Oct 15, 2020 |
| Original Closing Date for Applications: | Jan 07, 2024 |
| Current Closing Date for Applications: | Jan 07, 2024 |
| Archive Date: | Feb 12, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts City or township governments State governments For profit organizations other than small businesses Public and State controlled institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) intends to support investigators who have interest and capability to join efforts for the discovery of cell-based chemical probes for novel brain targets. It is expected that applicants will have in hand the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds. Through this FOA, NIH wishes to stimulate research in: 1) discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of NIMH, NIA, NICHD, and/or NIDCD; and 2) discovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms. Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes. The main emphasis of projects submitted under this FOA should be in the discovery of cell-based chemical probes. Applicants interested in developingin vivochemical probes may wish to apply using the companion R01 mechanism TEMP-8444. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-21-028.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 329437 Full Announcement-PAR-21-028 -> PAR-21-028-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00263780 | Jan 16, 2021 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00270281 | Nov 16, 2021 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00278117 | Nov 08, 2022 | Jan 07, 2024 | View |
Package 1
Mandatory forms
329437 RR_SF424_2_0-2.0.pdf
329437 PHS398_CoverPageSupplement_5_0-5.0.pdf
329437 RR_OtherProjectInfo_1_4-1.4.pdf
329437 PerformanceSite_2_0-2.0.pdf
329437 RR_KeyPersonExpanded_2_0-2.0.pdf
329437 PHS398_ResearchPlan_4_0-4.0.pdf
329437 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
329437 RR_Budget_1_4-1.4.pdf
329437 RR_SubawardBudget30_1_4-1.4.pdf
329437 PHS398_ModularBudget_1_2-1.2.pdf
329437 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
329437 RR_SF424_5_0-5.0.pdf
329437 PHS398_CoverPageSupplement_5_0-5.0.pdf
329437 RR_OtherProjectInfo_1_4-1.4.pdf
329437 PerformanceSite_4_0-4.0.pdf
329437 RR_KeyPersonExpanded_4_0-4.0.pdf
329437 PHS398_ResearchPlan_4_0-4.0.pdf
329437 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
329437 RR_Budget_3_0-3.0.pdf
329437 RR_SubawardBudget30_3_0-3.0.pdf
329437 PHS398_ModularBudget_1_2-1.2.pdf
329437 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 3
Mandatory forms
329437 RR_SF424_5_0-5.0.pdf
329437 PHS398_CoverPageSupplement_5_0-5.0.pdf
329437 RR_OtherProjectInfo_1_4-1.4.pdf
329437 PerformanceSite_4_0-4.0.pdf
329437 RR_KeyPersonExpanded_4_0-4.0.pdf
329437 PHS398_ResearchPlan_5_0-5.0.pdf
329437 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
329437 RR_Budget_3_0-3.0.pdf
329437 RR_SubawardBudget30_3_0-3.0.pdf
329437 PHS398_ModularBudget_1_2-1.2.pdf
329437 PHS_AssignmentRequestForm_3_0-3.0.pdf
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