This NIH grant is for establishing Testing Centers focused on somatic cell genome editing in major mammalian model species like rodents, pigs, and non-human primates. These Centers will provide crucial resources and testing services to the scientific community, aiding the development and preclinical evaluation of novel genome editing technologies for human disease therapeutics. Collaborating with NIH-funded investigators, the Centers will assess the efficacy and safety of in vivo genome editing and delivery methods, determine optimal editing thresholds, and ascertain feasibility parameters in model systems. This initiative aims to generate vital data to validate treatment strategies and improve the safety and specificity of genome editing approaches, ultimately benefiting the broader biomedical community.
Opportunity ID: 344642
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-23-038 |
| Funding Opportunity Title: | Testing Centers for Development of Somatic Cell Genome Editing in Model Organisms (U42) (Clinical Trials Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.351 — Research Infrastructure Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 23, 2022 |
| Last Updated Date: | Nov 23, 2022 |
| Original Closing Date for Applications: | Feb 01, 2023 |
| Current Closing Date for Applications: | Feb 01, 2023 |
| Archive Date: | Mar 09, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments County governments City or township governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education Public housing authorities/Indian housing authorities State governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to support Testing Centers for Somatic Cell Genome Editing in specified major mammalian animal model species (rodents, pigs, and non-human primates). Each Center will provide resources and testing services to the growing community developing new genome editing technologies and conducting preclinical testing based upon these technologies for therapeutics of human diseases. The Testing Centers will work with NIH funded investigators to assess the efficacy and safety of in vivo genome editing and delivery technologies, determine genome editing thresholds for specific diseases associated with minimal off-target effects, and ascertain feasibility parameters in a model system. This data will be important in determining if a treatment strategy using a specific set of tools is effective and has an acceptable safety profile, or if the efficacy and specificity of editing should be significantly improved. Even though each Testing Center will work on a limited number of focused projects, it is expected that the program and pipeline(s) developed will maintain multifaceted research activities to build core model systems that can be adjusted as required to accommodate a broad spectrum of diseases as well as provide fee-for-service to the wider biomedical community on a national basis. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-23-038.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 344642 Full Announcement-PAR-23-038 -> PAR-23-038-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00278989 | Jan 01, 2023 | Feb 01, 2023 | View |
Package 1
Mandatory forms
344642 RR_SF424_5_0-5.0.pdf
344642 PHS398_CoverPageSupplement_5_0-5.0.pdf
344642 RR_OtherProjectInfo_1_4-1.4.pdf
344642 PerformanceSite_4_0-4.0.pdf
344642 RR_KeyPersonExpanded_4_0-4.0.pdf
344642 PHS398_ResearchPlan_5_0-5.0.pdf
344642 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
344642 PHS_Additional_IndirectCosts_2_0-2.0.pdf
344642 PHS_AssignmentRequestForm_3_0-3.0.pdf
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