The NIH is offering a grant focused on harnessing Extracellular RNA (exRNA) for therapeutic development. ExRNA, present in various body fluids, is increasingly recognized for its role in intercellular signaling by altering target cell phenotypes. This initiative aims to develop novel therapies based on exRNA signaling, demonstrating their potential clinical utility. Projects should also focus on creating tools and technologies for engineering and packaging specific RNAs into extracellular vesicles or associating them with RNA-binding proteins. The ultimate goal is to enable efficient extracellular delivery of these therapeutic RNAs to target cells, covering methods for their production, purification, packaging, and targeted delivery.
Opportunity ID: 189274
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-RM-12-014 |
| Funding Opportunity Title: | Clinical Utility of Extracellular RNA for Therapy Development (UH2/UH3) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.310 — Trans-NIH Research Support |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 03, 2012 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 13, 2012 |
| Current Closing Date for Applications: | Nov 13, 2012 |
| Archive Date: | Dec 14, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education State governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Special district governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Extracellular RNA (exRNA) is present in human body fluids, such as blood, saliva, urine, breast milk, amniotic fluid, cerebrospinal fluid, ascites and pleural effusions. The concept that secreted exRNA can alter target cell phenotypes is emerging as a universal and novel paradigm in intercellular signaling. In view of this emerging paradigm, the NIH invites applications for projects that will develop novel therapies based on exRNA signaling. The overall goal of this initiative is to develop and demonstrate the potential for clinical utility of exRNAs as therapeutic agents, and to develop tools and technologies to enable engineered RNAs to be packaged into extracellular vesicles or associated with RNA-binding proteins for use as extracellular delivery vehicles. These projects should include methods for the production, purification, and packaging of specific RNAs and methods to deliver them to target cells via extracellular space. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-12-014.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.310 | ADOBE-FORMS-B2 | ADOBE-FORMS-B2 | PKG00136452 | Oct 12, 2012 | Nov 13, 2012 | View |
Package 1
Mandatory forms
189274 RR_SF424_1_2-1.2.pdf
189274 PerformanceSite_1_4-1.4.pdf
189274 RR_OtherProjectInfo_1_3-1.3.pdf
189274 RR_KeyPersonExpanded_1_2-1.2.pdf
189274 RR_Budget-1.1.pdf
189274 PHS398_CoverPageSupplement_1_4-1.4.pdf
189274 PHS398_ResearchPlan_1_3-1.3.pdf
189274 PHS398_Checklist_1_3-1.3.pdf
Optional forms
189274 RR_SubawardBudget30-1.2.pdf
189274 PHS_CoverLetter_1_2-1.2.pdf
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