The National Institutes of Health (NIH) is offering this R01 grant to advance the study of HIV latency and pathology using human cell-animal chimera brain models. Recent technical advancements facilitate generating human-mouse chimeric brains by engrafting human neural and microglial progenitor cells, which functionally integrate. This grant is for developing a rodent model to define the structure and function of human-containing neural networks. It aims to investigate HIV infectivity, reservoir formation, and neuropathogenesis, including HIV and substance abuse comorbidity. This research will utilize a fully functional, awake animal model, studying the disease from single cell to neural circuitry levels.
Opportunity ID: 328081
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DA-21-026 |
| Funding Opportunity Title: | Using Human Cell Animal Chimera Brains to Study HIV Latency and Pathology R01 – Clinical Trials Not Allowed |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Abuse and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 13, 2020 |
| Last Updated Date: | Jul 13, 2020 |
| Original Closing Date for Applications: | Nov 13, 2020 |
| Current Closing Date for Applications: | Nov 13, 2020 |
| Archive Date: | Dec 19, 2020 |
| Estimated Total Program Funding: | $1,500,000 |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education City or township governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Recent technical advancements have enabled generating human cell-mice chimeric brains by engrafting human iPSC-derived primitive neural progenitor cells and/or cord blood-derived microglial progenitor cells into neonatal mouse. In the chimeric brain, human neural progenitor cells or microglial cells differentiate, migrate, and distribute throughout the mouse brain. They are eventually functionally integrated into various brain regions. Such successes provide opportunities to define the structure, function, genetics and plasticity of functional neural networks containing human cells. It can also serve as a rodent model to study HIV infectivity, provirus activity, reservoir formation, and the neuropathogenesis of HIV infection. It allows the study of HIV and substance abuse comorbidity in the brain of a fully functional, awake, behaving animal from the single cell to neural circuitry levels. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-21-026.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00262545 | Oct 13, 2020 | Nov 13, 2020 | View |
Package 1
Mandatory forms
328081 RR_SF424_2_0-2.0.pdf
328081 PHS398_CoverPageSupplement_5_0-5.0.pdf
328081 RR_OtherProjectInfo_1_4-1.4.pdf
328081 PerformanceSite_2_0-2.0.pdf
328081 RR_KeyPersonExpanded_2_0-2.0.pdf
328081 PHS398_ResearchPlan_4_0-4.0.pdf
328081 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
328081 RR_Budget_1_4-1.4.pdf
328081 RR_SubawardBudget30_1_4-1.4.pdf
328081 PHS398_ModularBudget_1_2-1.2.pdf
328081 PHS_AssignmentRequestForm_3_0-3.0.pdf
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