The National Institutes of Health (NIH) is offering this grant to support research investigating the earliest synaptic activity and circuit plasticity changes contributing to neurodegeneration in Alzheimer’s disease and related dementias (AD/ADRD). This grant aims to develop and utilize models for a mechanistic understanding of AD/ADRD onset and progression, focusing on prodromal synaptic, circuit, and network alterations. The goal is to identify early changes to inform future interventions. Applicants should leverage NIH BRAIN program technologies and include animal-based studies validating cell or organoid findings. Projects relying entirely on cell or organoid systems are not eligible.
Opportunity ID: 336396
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-059 |
| Funding Opportunity Title: | Prodromal Synaptic and Circuit Changes that Contribute to AD/ADRD Onset and Progression (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 03, 2021 |
| Last Updated Date: | Nov 03, 2021 |
| Original Closing Date for Applications: | Feb 05, 2022 |
| Current Closing Date for Applications: | Feb 05, 2022 |
| Archive Date: | Mar 13, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments For profit organizations other than small businesses County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses Native American tribal governments (Federally recognized) State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this FOA is to develop and use models to investigate the contribution of synaptic activity and circuit plasticity changes to the progression of disease processes that underlie neurodegeneration in dementia. The overall goal is to understand, from a mechanistic standpoint, the earliest synaptic, circuit and network changes that contribute to AD/ADRD disease onset and pathogenesis. A better in vivo mechanistic understanding of synaptic activity and circuit plasticity changes that underlie the earliest stages of neurodegeneration in AD/ADRD should increase opportunities for developing future interventions. Utilizing technology developed in NIH BRAIN programs is encouraged, including animal-based studies that validate in vivo relevance of findings based on cell-based or organoid-based research. Applications that rely entirely on cell-based or organoid-based systems are out of scope. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-22-059.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 336396 Full Announcement-PAR-22-059 -> PAR-22-059-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00269983 | Jan 05, 2022 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00270202 | Jan 05, 2022 | Feb 05, 2022 | View |
Package 1
Mandatory forms
336396 RR_SF424_2_0-2.0.pdf
336396 PHS398_CoverPageSupplement_5_0-5.0.pdf
336396 RR_OtherProjectInfo_1_4-1.4.pdf
336396 PerformanceSite_2_0-2.0.pdf
336396 RR_KeyPersonExpanded_2_0-2.0.pdf
336396 PHS398_ResearchPlan_4_0-4.0.pdf
336396 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
336396 RR_Budget_1_4-1.4.pdf
336396 RR_SubawardBudget30_1_4-1.4.pdf
336396 PHS398_ModularBudget_1_2-1.2.pdf
336396 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
336396 RR_SF424_5_0-5.0.pdf
336396 PHS398_CoverPageSupplement_5_0-5.0.pdf
336396 RR_OtherProjectInfo_1_4-1.4.pdf
336396 PerformanceSite_4_0-4.0.pdf
336396 RR_KeyPersonExpanded_4_0-4.0.pdf
336396 PHS398_ResearchPlan_4_0-4.0.pdf
336396 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
336396 RR_Budget_3_0-3.0.pdf
336396 RR_SubawardBudget30_3_0-3.0.pdf
336396 PHS398_ModularBudget_1_2-1.2.pdf
336396 PHS_AssignmentRequestForm_3_0-3.0.pdf
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