This NIH grant, offered in collaboration with the International Mouse Phenotyping Consortium (IMPC) and the NIH Knockout Mouse Phenotyping Program (KOMP2), is designed to encourage applications for phenotyping embryonic lethal knockout (KO) mouse strains. As IMPC and KOMP2 are generating an estimated 20,000 mouse strains, with approximately 30% expected to be embryonic or perinatal lethal, this initiative offers a unique opportunity. The purpose is to leverage these newly created and bred mouse strains to identify and characterize viable heterozygous phenotypes, which are anticipated for a large portion of homozygous lethal mutations. This effort aims to advance our understanding of genetic functions and disease mechanisms by thoroughly phenotyping these critical mouse models as they become available.
Opportunity ID: 235335
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-13-231 |
| Funding Opportunity Title: | Phenotyping Embryonic Lethal Knockout Mice (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Food and Nutrition Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | May 22, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Sep 07, 2016 |
| Current Closing Date for Applications: | Sep 07, 2016 |
| Archive Date: | Oct 08, 2016 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $499,999 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Independent school districts Public housing authorities/Indian housing authorities For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) Private institutions of higher education Small businesses City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to phenotype embryonic lethal knockout (KO) mouse strains being generated through the International Mouse Phenotyping Consortium (IMPC) of which the NIH Knockout Mouse Phenotyping Program (KOMP2) is a member. It is estimated that KO mouse phenotyping efforts will generate 20,000 mouse strains over the next decade of which about 30% will be embryonic or perinatal lethal. A large portion of homozygous lethal mutations are expected to have viable heterozygous phenotypes. The scientific community has the unique opportunity to leverage these mouse strains while they are being created and bred as part of the IMPC adult mouse phenotyping effort. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-13-231.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | Use for due dates after 9/24/2013 | PKG00179833 | Sep 05, 2013 | Apr 16, 2016 | View | |
| FORMS-D | Use for due dates on or after May 25, 2016 | PKG00221995 | Apr 17, 2016 | Sep 07, 2016 | View |
Package 1
Mandatory forms
235335 RR_SF424_2_0-2.0.pdf
235335 PHS398_ResearchPlan_2_0-2.0.pdf
235335 PHS398_CoverPageSupplement_2_0-2.0.pdf
235335 RR_KeyPersonExpanded_2_0-2.0.pdf
235335 RR_OtherProjectInfo_1_3-1.3.pdf
235335 PerformanceSite_2_0-2.0.pdf
Optional forms
235335 RR_SubawardBudget30_1_3-1.3.pdf
235335 PlannedReport-1.0.pdf
235335 PHS398_CumulativeInclusionReport-1.0.pdf
235335 PHS398_ModularBudget_1_2-1.2.pdf
235335 RR_Budget_1_3-1.3.pdf
Package 2
Mandatory forms
235335 RR_SF424_2_0-2.0.pdf
235335 PHS398_CoverPageSupplement_3_0-3.0.pdf
235335 RR_OtherProjectInfo_1_3-1.3.pdf
235335 PerformanceSite_2_0-2.0.pdf
235335 RR_KeyPersonExpanded_2_0-2.0.pdf
235335 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
235335 RR_Budget_1_3-1.3.pdf
235335 RR_SubawardBudget30_1_3-1.3.pdf
235335 PHS398_ModularBudget_1_2-1.2.pdf
235335 PHS_Inclusion_Enrollment_Report-1.0.pdf
235335 PHS_AssignmentRequestForm-1.0.pdf
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