This NIH grant invites research addressing persistent HIV-1 in central nervous system (CNS) reservoirs of individuals on Highly Active Anti-Retroviral Therapy (HAART). It supports innovative studies aimed at eradicating HIV-1 from the CNS. Key research areas include identifying and characterizing persistent HIV-1 in CNS cells (macrophages, microglia, astrocytes), understanding establishment mechanisms, and developing relevant animal/cellular models of persistence (including substance use effects). The grant also assesses current/emerging eradication strategies for reactivating persistent HIV from CNS cells and evaluating their toxicity. Both basic and translational research, domestic and international, are encouraged.
Opportunity ID: 229998
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-14-171 |
| Funding Opportunity Title: | Eradication of HIV-1 from CNS Reservoirs: Implications for Therapeutics (R21) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 10, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Sep 17, 2013 |
| Current Closing Date for Applications: | Sep 17, 2013 |
| Archive Date: | Oct 18, 2013 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) State governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts Special district governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments For profit organizations other than small businesses County governments Small businesses Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) invites research grant applications to address the problem of HIV-1 persistence focused solely on the central nervous system (CNS) of HIV-infected persons treated with Highly Active Anti-Retroviral Therapy (HAART). This FOA will support innovative research in five areas: (1) basic research to identify and characterize persistent HIV-1 in CNS derived cells such as macrophages, microglia and/or astrocytes in the setting of suppressive anti-retroviral therapy, with or without substance use; (2) basic research to determine the mechanisms involved in the temporal establishment, maintenance, and resurgence of persistent HIV-1 in CNS in relationship to the timing of antiretroviral therapy; (3) development of physiologically relevant animal models and CNS-based cellular assays that recapitulate HIV-1 persistence and latency in the presence of effective HAART, including effects of chronic substance use; (4) assessment of current and emerging eradication approaches on whether and/or how well they have successfully reactivated persistent HIV from CNS-derived cells such as macrophages, microglia and astrocytes; and (5) assessment of CNS toxicity and adverse impact of current and emerging eradication strategies. Applications ranging from basic to translational research in domestic and international settings are of interest. Multidisciplinary research teams are encouraged but not required. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-14-171.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B2 | Adobe-Forms-B2 | PKG00173239 | Aug 17, 2013 | Sep 17, 2013 | View |
Package 1
Mandatory forms
229998 RR_SF424_1_2-1.2.pdf
229998 PerformanceSite_1_4-1.4.pdf
229998 RR_OtherProjectInfo_1_3-1.3.pdf
229998 RR_KeyPersonExpanded_1_2-1.2.pdf
229998 PHS398_CoverPageSupplement_1_4-1.4.pdf
229998 PHS398_ResearchPlan_1_3-1.3.pdf
229998 PHS398_Checklist_1_3-1.3.pdf
Optional forms
229998 RR_SubawardBudget30-1.2.pdf
229998 PHS398_ModularBudget_1_2-1.2.pdf
229998 RR_Budget-1.1.pdf
229998 PHS_CoverLetter_1_2-1.2.pdf
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