The National Institutes of Health (NIH) is offering this grant to investigate HIV-associated CNS complications, which persist despite effective anti-retroviral therapy. These complications, including cognitive, neurological, and mental health issues, arise early in infection. Despite extensive data on underlying pathophysiology, specific causal mechanisms and effective therapies remain elusive. This grant aims to comprehend actionable biotypes of CNS complications in people living with HIV, focusing on their underlying mechanisms. By identifying these biotypes, the initiative seeks to capture the heterogeneity of outcomes, which is crucial for informing the development of targeted, precision treatment strategies. This grant is for advancing understanding to develop new interventions.
Opportunity ID: 350031
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-24-235 |
| Funding Opportunity Title: | Biotypes of CNS Complications in People Living with HIV (P01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 29, 2023 |
| Last Updated Date: | Aug 29, 2023 |
| Original Closing Date for Applications: | Dec 11, 2023 |
| Current Closing Date for Applications: | Dec 11, 2023 |
| Archive Date: | Jan 16, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments City or township governments Native American tribal governments (Federally recognized) Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | HIV associated CNS complications are a significant problem for people living with HIV despite suppressive anti-retroviral therapy. HIV enters the CNS as early as 8 days after infection and can cause several complications including cognitive, neurological and mental health related issues. Although experts have gathered much data on underlying HIV-induced CNS pathophysiology, specific targeted causality remains elusive, and no effective therapies exist to slow, stop, or reverse these adverse outcomes. This initiative is to comprehend the actionable biotypes of CNS complications in people living with HIV based on underlying mechanisms to help capture the heterogeneity of outcomes. Identifying biotypes can inform the development of precision treatment strategies for CNS complications seen in people living with HIV. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-24-235.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 350031 Full Announcement-RFA-MH-24-235 -> RFA-MH-24-235-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00283012 | Nov 11, 2023 | Dec 11, 2023 | View |
Package 1
Mandatory forms
350031 RR_SF424_5_0-5.0.pdf
350031 PHS398_CoverPageSupplement_5_0-5.0.pdf
350031 RR_OtherProjectInfo_1_4-1.4.pdf
350031 PerformanceSite_4_0-4.0.pdf
350031 RR_KeyPersonExpanded_4_0-4.0.pdf
350031 PHS398_ResearchPlan_5_0-5.0.pdf
350031 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
350031 PHS_Additional_IndirectCosts_2_0-2.0.pdf
350031 PHS_AssignmentRequestForm_3_0-3.0.pdf
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