The National Institutes of Health (NIH) is offering this grant to support projects focused on developing integrated microphysiological systems for comprehensive drug efficacy and toxicity testing. This funding opportunity aims to create accurate cellular and organ microsystems that accurately represent human physiology. This grant is for the purpose of advancing the evaluation of drug safety and effectiveness in human health and disease. These bio-engineered models must feature a multicellular architecture reflective of original tissues, demonstrating reproducible and viable operation over extended culture periods under physiological conditions. It is anticipated these innovative human tissue models will lead to the development and commercialization of microsystems, enabling rapid and highly reliable evaluation of candidate therapeutics’ safety and efficacy.
Opportunity ID: 131753
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-RM-11-022 |
| Funding Opportunity Title: | Integrated Microphysiological Systems for Drug Efficacy and Toxicity Testing in Human Health and Disease (UH2/UH3) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.310 — Trans-NIH Research Support |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 22, 2011 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jan 26, 2012 |
| Current Closing Date for Applications: | Jan 26, 2012 |
| Archive Date: | Feb 26, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Public and State controlled institutions of higher education Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Private institutions of higher education Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This NIH Funding Opportunity Announcement (FOA), supported by funds from the NIH Common Fund (Common Fund) and participating NIH Institute(s) and Center(s), invites applications for projects that will develop accurate cellular and organ microsystems representative of human physiology for the evaluation of drug efficacy and toxicity. By definition, these cellular and organ microsystems will have a multicellular architecture representing the characteristics and functions of the tissue of origin and will demonstrate a reproducible and viable operation under physiological conditions over a long culture period. It is anticipated that these bio-engineered human tissue models could lead to the development and commercialization of microsystems that will enable rapid and high fidelity evaluation of safety and efficacy for candidate therapeutics. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-11-022.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.310 | ADOBE-FORMS-B2 | ADOBE-FORMS-B2 | PKG00086490 | Dec 26, 2011 | Jan 26, 2012 | View |
Package 1
Mandatory forms
131753 RR_SF424_1_2-1.2.pdf
131753 PerformanceSite_1_4-1.4.pdf
131753 RR_OtherProjectInfo_1_3-1.3.pdf
131753 RR_KeyPersonExpanded_1_2-1.2.pdf
131753 RR_Budget-1.1.pdf
131753 PHS398_CoverPageSupplement_1_4-1.4.pdf
131753 PHS398_ResearchPlan_1_3-1.3.pdf
131753 PHS398_Checklist_1_3-1.3.pdf
Optional forms
131753 RR_SubawardBudget30-1.2.pdf
131753 PHS_CoverLetter_1_2-1.2.pdf
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