The National Institutes of Health (NIH) is offering this grant to investigate bladder cancer biology and mechanisms. This grant addresses the significant burden of bladder cancer, marked by high incidence and recurrence. Despite molecular profiling advances, understanding mechanisms driving initiation, progression, and malignancy is limited. Knowledge of normal bladder molecular and cellular biology is also scarce. This opportunity seeks fundamental insights into how bladder functions alter in cancer, crucial for interventions. Multidisciplinary teams, clinical specimens, and research spanning normal and cancer processes are encouraged.
Opportunity ID: 357252
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-129 |
| Funding Opportunity Title: | Biology of Bladder Cancer (R01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 20, 2024 |
| Last Updated Date: | Nov 20, 2024 |
| Original Closing Date for Applications: | Sep 07, 2025 |
| Current Closing Date for Applications: | Sep 07, 2025 |
| Archive Date: | Oct 13, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Public housing authorities/Indian housing authorities Small businesses Public and State controlled institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Private institutions of higher education County governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Through this Notice of Funding Opportunity (NOFO) solicits applications investigating the biology and underlying mechanisms of bladder cancer. Bladder cancer is a significant health problem both in the United States and globally. Because of the high incidence and frequent tumor recurrence, bladder cancer exacts an outsized medical burden. While recent progress has been made in the molecular profiling of bladder cancers and identification of mutated genes, relatively little is known regarding the molecular mechanisms driving initiation, progression, and malignancy of bladder cancer. Furthermore, our understanding of biological processes of the normal bladder at the molecular, cell and organ levels is limited. Fundamental knowledge of how molecular and cellular functions of the bladder are altered in cancer will aid our understanding of bladder cancer biology and interventions. Applications that involve multidisciplinary teams and use clinical specimens or investigate both normal and cancer processes are encouraged. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-129.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357252 Full Announcement-PAR-25-129 -> PAR-25-129-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288832 | Jan 05, 2025 | Sep 07, 2025 | View |
Package 1
Mandatory forms
357252 RR_SF424_5_0-5.0.pdf
357252 PHS398_CoverPageSupplement_5_0-5.0.pdf
357252 RR_OtherProjectInfo_1_4-1.4.pdf
357252 PerformanceSite_4_0-4.0.pdf
357252 RR_KeyPersonExpanded_4_0-4.0.pdf
357252 PHS398_ResearchPlan_5_0-5.0.pdf
357252 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357252 RR_Budget_3_0-3.0.pdf
357252 RR_SubawardBudget30_3_0-3.0.pdf
357252 PHS398_ModularBudget_1_2-1.2.pdf
357252 PHS_AssignmentRequestForm_4_0-4.0.pdf
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