The National Institutes of Health (NIH) is offering this grant to support basic research aimed at elucidating the mechanisms behind Fc-mediated antibody functions. This funding opportunity specifically targets studies focusing on antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP). The grant’s purpose is to generate foundational data and robust tools to predict Fc-mediated killing activity by antibodies. Such advancements are crucial for accelerating the development of therapeutic monoclonal antibodies. Furthermore, this research will aid in designing effective vaccines or vaccine-adjuvant combinations capable of inducing potent antibody responses for killing infected host cells, particularly in scenarios where neutralizing antibodies are insufficient for infection clearance.
Opportunity ID: 350342
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-23-054 |
| Funding Opportunity Title: | Fc-Dependent Mechanisms of Antibody-Mediated Killing (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 26, 2023 |
| Last Updated Date: | Sep 26, 2023 |
| Original Closing Date for Applications: | Jan 26, 2024 |
| Current Closing Date for Applications: | Jan 26, 2024 |
| Archive Date: | Mar 02, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $300,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Private institutions of higher education Independent school districts Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Special district governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this notice of funding opportunity (NOFO) is to support basic research that will elucidate mechanisms of Fc-mediated antibody functions, including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP). Supported studies are expected to generate foundational data and tools that can be applied to the prediction of Fc-mediated killing activity by antibodies. Such data should accelerate development of therapeutic monoclonal antibodies and design of vaccines or vaccine-adjuvant combinations that induce antibody responses capable of killing infected host cells, particularly in cases where induction of neutralizing antibodies fails or is insufficient for clearance of infection |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-23-054.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 350342 Full Announcement-RFA-AI-23-054 -> RFA-AI-23-054-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00283260 | Dec 26, 2023 | Jan 26, 2024 | View |
Package 1
Mandatory forms
350342 RR_SF424_5_0-5.0.pdf
350342 PHS398_CoverPageSupplement_5_0-5.0.pdf
350342 RR_OtherProjectInfo_1_4-1.4.pdf
350342 PerformanceSite_4_0-4.0.pdf
350342 RR_KeyPersonExpanded_4_0-4.0.pdf
350342 PHS398_ResearchPlan_5_0-5.0.pdf
350342 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
350342 RR_Budget_3_0-3.0.pdf
350342 RR_SubawardBudget30_3_0-3.0.pdf
350342 PHS398_ModularBudget_1_2-1.2.pdf
350342 PHS_AssignmentRequestForm_3_0-3.0.pdf
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