This NIH grant supports exploratory/developmental basic research to elucidate how the human microbiome modulates anti-tumor immune responses. The primary purpose is to identify mechanisms by which specific microbes, consortia, or their metabolites either inhibit or enhance the body’s immune defense against cancer. Research should delineate host-microbe interactions that influence immune responses, impacting inflammation-associated or sporadic tumor formation. A key objective is to identify novel molecular targets for cancer prevention strategies. Applicants must rigorously address concentration, timing, and duration of administered beneficial microbes to ensure effectiveness. This grant aims to advance understanding of microbiome-immune interactions for future cancer interventions.
Opportunity ID: 336392
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-062 |
| Funding Opportunity Title: | Modulating Human Microbiome Function to Enhance Immune Responses Against Cancer (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 03, 2021 |
| Last Updated Date: | Nov 03, 2021 |
| Original Closing Date for Applications: | Jan 07, 2025 |
| Current Closing Date for Applications: | Jan 07, 2025 |
| Archive Date: | Feb 12, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $275,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments For profit organizations other than small businesses State governments Private institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to support exploratory/development basic research projects that elucidate mechanisms by which the human microbiome inhibit or enhance anti-tumor immune responses, and to identify potential novel molecular targets for cancer prevention strategies. Applications should be focused on delineating how host interactions with specific microbes (or consortia) or their metabolites targets immune responses that enhance or prevent inflammation-associated or sporadic tumor formation. Concentration, timing, and duration of administered beneficial microbes may alter its effectiveness and thus those parameters should be rigorously addressed in the application. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-22-062.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 336392 Full Announcement-PAR-22-062 -> PAR-22-062-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00270003 | Jan 16, 2022 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00270330 | Jan 16, 2022 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or before January 24, 2025 | PKG00278143 | Nov 08, 2022 | Jan 24, 2025 | View |
Package 1
Mandatory forms
336392 RR_SF424_2_0-2.0.pdf
336392 PHS398_CoverPageSupplement_5_0-5.0.pdf
336392 RR_OtherProjectInfo_1_4-1.4.pdf
336392 PerformanceSite_2_0-2.0.pdf
336392 RR_KeyPersonExpanded_2_0-2.0.pdf
336392 PHS398_ResearchPlan_4_0-4.0.pdf
336392 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
336392 RR_Budget_1_4-1.4.pdf
336392 RR_SubawardBudget30_1_4-1.4.pdf
336392 PHS398_ModularBudget_1_2-1.2.pdf
336392 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
336392 RR_SF424_5_0-5.0.pdf
336392 PHS398_CoverPageSupplement_5_0-5.0.pdf
336392 RR_OtherProjectInfo_1_4-1.4.pdf
336392 PerformanceSite_4_0-4.0.pdf
336392 RR_KeyPersonExpanded_4_0-4.0.pdf
336392 PHS398_ResearchPlan_4_0-4.0.pdf
336392 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
336392 RR_Budget_3_0-3.0.pdf
336392 RR_SubawardBudget30_3_0-3.0.pdf
336392 PHS398_ModularBudget_1_2-1.2.pdf
336392 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 3
Mandatory forms
336392 RR_SF424_5_0-5.0.pdf
336392 PHS398_CoverPageSupplement_5_0-5.0.pdf
336392 RR_OtherProjectInfo_1_4-1.4.pdf
336392 PerformanceSite_4_0-4.0.pdf
336392 RR_KeyPersonExpanded_4_0-4.0.pdf
336392 PHS398_ResearchPlan_5_0-5.0.pdf
336392 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
336392 RR_Budget_3_0-3.0.pdf
336392 RR_SubawardBudget30_3_0-3.0.pdf
336392 PHS398_ModularBudget_1_2-1.2.pdf
336392 PHS_AssignmentRequestForm_3_0-3.0.pdf
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